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Abstract

The development of connections within the human brain is perhaps the most complex feat of self-organization known to science. Billions of neurons must be carefully and specifically con-nected up in order for us to function properly. Each neuron forms up to tens of thousands of connections to other neurons, and these con-nections may span distances of micrometers up to several centimeters. The precise targeting of individual connections is finely tuned, and the consequences of errors in this targeting are profound, with many important neurolog ical and psychiatric conditions now linked to defects in this neural wiring [1,2]. It is imperative that we understand how normal wiring develops, s

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