oaioai:CiteSeerX.psu:10.1.1.598.2649

Selective activation of protein kinase C isoforms by v-Src. Cell Growth Differ

Abstract

Protein kinase C (PKC) is a gene family consisting of no less than 1 1 distind isoforms. In both murine and rat fibroblasts, we deteded expression of four PKC isoforms: the conventional PKC a, the novel PKCs 6 and #{128},and the atypical PKC . With the conventional and novel PKC isoforms, membrane association has been used to show PKC adivation. In cells transformed by v-Src, there was a Ca2-dependent increase in membrane association of the a isoform relative to the nontransformed parental cells. The isoform had a slightly increased membrane association in murine fibroblasts transformed by v-Src but not in rat fibroblasts transformed by v-Src. However, since it is not clear whether cellular distribution of isoform correlates with adivation, the data are inconclusive with regard to thi

Similar works

Full text

thumbnail-image
oaioai:CiteSeerX.psu:10.1.1.598.2649Last time updated on 10/29/2017

This paper was published in CiteSeerX.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.