Selective activation of protein kinase C isoforms by v-Src. Cell Growth Differ


Protein kinase C (PKC) is a gene family consisting of no less than 1 1 distind isoforms. In both murine and rat fibroblasts, we deteded expression of four PKC isoforms: the conventional PKC a, the novel PKCs 6 and #{128},and the atypical PKC . With the conventional and novel PKC isoforms, membrane association has been used to show PKC adivation. In cells transformed by v-Src, there was a Ca2-dependent increase in membrane association of the a isoform relative to the nontransformed parental cells. The isoform had a slightly increased membrane association in murine fibroblasts transformed by v-Src but not in rat fibroblasts transformed by v-Src. However, since it is not clear whether cellular distribution of isoform correlates with adivation, the data are inconclusive with regard to thi

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