Graduation date: 1993Fifteen adenoviruses from cattle, sheep, horses, and llamas were studied by\ud virus neutralization to determine their degree of antigenic similarity. Prototype viruses\ud included bovine adenoviruses species 1-8, ovine adenoviruses species 5 and\ud 6, and equine adenovirus species 1. Unclassified viruses that were compared to\ud the prototype viruses were isolated from different locations within Oregon and\ud were represented by bovine isolate 32CN, ovine isolates 47F and 475N, and llama\ud isolate 7649. Reciprocal virus neutralization tests were performed and the degree\ud of antigenic similarity, i.e., species differentiation was determined by criteria established\ud by the International Committee for the Nomenclature of Viruses.\ud The study showed that many of the adenoviruses, both prototype and unclassified,\ud shared minor antigenic components with each other. Prototype viruses possessed\ud major antigenic differences and, as previously demonstrated by other\ud investigators, should be classified as separate virus species. Bovine adenovirus\ud isolate 32CN was shown to be of the same species as ovine adenovirus isolate\ud 475N, but neither isolate was similar to any of the prototype virus species studied.\ud Ovine adenovirus isolate 47F was shown to be of the same species as ovine adenovirus\ud species 5 strain RTS 42. Llama adenovirus isolate 7649, while sharing minor\ud antigens with different viruses from cattle and sheep, was shown to be a distinct \ud species. This represents the first species of adenovirus from llama
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