Graduation date: 1999This report describes the partial characterization of the first cultivable calicivirus isolated from a European rabbit (Oryctolagus cuniculus), named rabbit calicivirus Oryctolagus-1 and abbreviated RaCv Ory-1. RaCv Ory-1 was isolated from juvenile feeder rabbits displaying symptoms of diarrhea. Absence of neutralization by type specific neutralizing antibodies for 40 caliciviruses and phylogenetic sequence comparisons among the caliciviruses of partial ORF1 and complete ORF2 and ORF3 sequences demonstrate that RaCv Ory-1 is a novel member of the marine calicivirus sub-group. Phylogenetic evaluation of the Caliciviridae indicates that analyses using pooled 3D-polymerase and capsid sequences are more statistically robust than identically executed analyses of single gene sequence data. Phylogenetic analysis of pooled 3D-polymerase and capsid\ud a.a. sequences show canine calicivirus isolate 48 (CaCv-48) to be an intermediate species which forms a node approximately equidistant to the feline, marine, and Sapporo-like caliciviruses. RaCV Ory-1 is suggested as a possible cultivable model of rabbit hemorrhagic disease virus
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