oaioai:CiteSeerX.psu:10.1.1.574.6734

Letters to the Editor

Abstract

Total and active ghrelin levels in women with polycystic ovary syndrome Sir, We read with interest the recent manuscript by Panidis et al. (2005) determining the correlation of ghrelin with the meta-bolic and hormonal features of women with polycystic ovary syndrome (PCOS). Although the investigators should be con-gratulated for their observations on a large group of PCOS patients, we would like to bring to your attention some issues concerning the measurement and structural characteristics of ghrelin. Although the authors correctly described ghrelin activities, they did not clarify that ghrelin requires post-translational n-octanoylation of the Ser 3-hydroxyl group for its activity (Kojima et al., 1999; Hosoda et al., 2000a). This acylation ena

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oaioai:CiteSeerX.psu:10.1.1.574.6734Last time updated on 10/29/2017

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