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MOLECULAR REPRODUCTION AND DEVELOPMENT 69:94–100 (2004) The Regulation of Competence to Replicate in Meiosis by Cdc6 Is Conserved During Evolution



ABSTRACT DNA replication licensing is an important step in the cell cycle at which cells become competent for DNA replication. When the cell cycle is arrested for long periods of time, this competence is lost. This is the case for somatic cells arrested in G0 or vertebrate oocytes arrested in G2. CDC6 is a factor involved in replication initiation competence which is necessary for the recruitment of the MCM helicase complex to DNA replication origins. In Xenopus, we have previously shown that CDC6 is the only missing replication factor in the oocyte whose translation during meiotic maturation is necessary and sufficient to confer DNA replication competence to the egg before fertiliza

Topics: Key Words, meiosis, Cdc6
Year: 2015
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