Enhanced Susceptibility to Oxidation and Diminished Vitamin E Content of LDL from Patients with Stable Coronary Artery Disease


modification of LDL as an important trigger in a com-plex chain of events leading to atherosclerosis. We investigated the occurrence of enhanced susceptibility of LDL to oxidation and decreased vitamin E concentra-tion in LDL as additional risk factors promoting athero-sclerosis among patients with established coronary ar-tery disease (CAD). Methods: We examined 132 patients with angiographi-cally confirmed CAD and compared them with 111 healthy control individuals. We measured conjugated diene production to assess susceptibility of LDL to copper-mediated oxidation. Vitamin E content of LDL was measured by HPLC. Results: The mean lag time of LDL oxidation and LDL a-tocopherol/LDL-cholesterol ratio were lower in the patients with CAD (55 6 14 min and 2.4 6 1.0 mmol/ mmol) than in the controls (63 6 13 min and 2.9 6 1.

Similar works

Full text

oaioai:CiteSeerX.psu:10.1...Last time updated on 10/28/2017

This paper was published in CiteSeerX.

Having an issue?

Is data on this page outdated, violates copyrights or anything else? Report the problem now and we will take corresponding actions after reviewing your request.