Differential cell counts have provided extensive data through more than a century of laboratory hematology. Routine bench morphology count continues to play a role in analyses of blood and other tissues such as bone marrow, but for many purposes it is being replaced by other tech-nologies that provide greater precision and consistency. This discussion of the differential cell count traces the development of electronic analysis and looks at the recent impact of monoclonal antibody鈥揵ased flow cytometry. The introduction of the extended differential count has led to a rapid increase in electronic analysis, with resultant increased accuracy, lower cost, and more efficient turn-around times. Moreover, the extended differential is leading to acquisition of effective data on complex specimens and is paving the way for new parameters in the field. Lab

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