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Measurement of sub-membrane [Ca2+] cytosolic [Ca2+] in myotubes from no 2+ tor b



The hypothesis that intracellular Ca2+ is elevated in dystrophic (mdx) skeletal muscle due to increased Ca2+ influx is controversial. As the sub-sarcolemmal Ca2+ ([Ca2+]mem) should be even higher than the global cytosolic Ca2+ in the presence of increased Ca2+ influx, we investigated [Ca2+]mem levels in collagenase-isolated adult flexor digitorum brevis (FDB) myofibres and myotubes of mdx and normal mice with the near difference in FFP-18. Inc FFP-18 was obtained wit controls as t cytosolic [C in isolated

Topics: C 1. Introdu Patients
Year: 2006
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