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CHEST Original Research ASTHMA



Increasing age is associated with worse asthma con-trol, 1 and mortality due to asthma increases sharply after age 65 years. 2 The reasons behind the age-related changes in clinical outcomes of asthma are unclear, and may be related to comorbidities in older patients, differing psychosocial circumstances, or physiologic changes associated with aging. The normal aging process leads to decreased lung function, 3 decreased lung elastic recoil, 4 and an altered expression of infl ammatory cells. 5 However, very few studies have examined the effect of these age-related changes on the pathophysiology of asthma in the elderly. If aging has independent effects on the pathophysiology of asthma, then the clinical expression of disease and its response to treatment will be different in old com-pared with young patients with asthma. It is, therefore

Year: 2014
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