WARTAZOA. Indonesian Bulletin of Animal and Veterinary Sciences
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    263 research outputs found

    A Systematic Review on the Role of the Respiratory and Intestinal Mucosal Immunity during Newcastle Disease Virus Infection

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    Newcastle disease (ND) is a devastating disease causing substantial economic losses due to high morbidity and mortality events worldwide in poultry. The disease is caused by the Newcastle disease virus (NDV), an enveloped, non-segmented single strand of negative-sense RNA approximately 15 kb in length. NDV can be classified as asymptomatic, lentogenic, mesogenic or velogenic pathotypes based on the levels of pathogenicity in chickens. The disease is being controlled by vaccination using either live-attenuated or inactivated vaccines. Various studies have been conducted to evaluate the association between mucosal immunity on NDV, however, the contribution of role of either respiratory or intestinal mucosal immunity remains to be revealed. Thus, the current study aimed to systematically review published articles about the role of respiratory and intestinal mucosal immunity during NDV infection. An online database search was performed through four different databases namely PubMed, Science Direct, JSTOR and Google Scholar using the following set of keywords: ‘Newcastle disease’, ‘Newcastle disease virus’, ‘respiratory’, ‘intestinal’ and ‘mucosal immunity’. Out of the 34,142 results, only 28 articles were suitable according to inclusion and exclusion criteria and were used for data extraction. Results showed that innate immunity was the most affected parameter when exposed to NDV infections, however, the role of respiratory and intestinal mucosal immunity against NDV infection remains widely uncharted. In conclusion, the role of the sub-components of respiratory and intestinal mucosal immunity toward NDV infection may become one of the determinant factors of protection for the chickens.

    The uniqueness of bats as natural host of viruses and their implication to global health

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    Bats are the natural host of several highly pathogenic viruses for human, such as SARS-CoV, Marburg, rabies, Hendra, Nipah, and ebola viruses. Bats did not show any clinical symptoms after infection with those highly pathogenic viruses. In addition, excessive inflammation and viremia were not developed in bats after viral infection. The absence of excessive inflammation is the compensation of their evolution as the only flying mammals. Their flight evolution also drives several unique features in their immune response that enable them to control the viral infection. This article summarizes current understandings about the uniqueness of bats as viral reservoir, the viral diversity in bats, the viral spillover from bats to human, and how to prevent the pandemic caused by emerging bat-borne viral zoonoses in the future. The understanding of how the antiviral response in bats work may provide valuable insights to control viral infection in human and domestic animals

    The Urgency of Identification of Extended Spectrum Beta-Lactamase (ESBL) Produced Bacteria in Indonesia

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    The Extended Spectrum Beta-Lactamase (ESBL) produced bacterias are the bacteria group that have resistant characteristic to beta-lactam antibiotics because of their ability to hydrolyze these antibiotics. This is a global health issue because they can reduce the treatment effectiveness and endanger human health. The ESBL produced bacterias were reported that they can be isolated from samples originated from animals, humans, and environment, indicating the potency of the resistant genes spreading widely. Therefore, it is necessary to take the preventive and control measures across sectors and stakeholders to limit the widespread transmission of resistant genes carried-bacteria, so the ESBL produced bacteria prevalence can be monitored. This article aims to present the studies of ESBL produced bacteria in Indonesia and the comparison with another country based on published journals and data. Even though these bacterias were identified in various samples, the reports from animals (wild and domestic) and the environment are still available in small numbers in Indonesia. The comprehensive studies from various fields (one health spectrum) in detection and surveillance are needed to support the awareness of antimicrobial resistance. Surveillance can be conducted thorough microbial approach such as culture and identification, and molecular methods. The surveillance data can be used as the source for planning and controlling program of antimicrobial resistance especially ESBL produced bacterias in Indonesia

    Antibiotic resistance in Escherichia coli from Animals, Food and Humans

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    Antibiotic resistance is considered a global public health problem and is related to the problem of resistance of bacteria in human and veterinary medicine that are transmitted directly and through the food chain. Uncontrolled use of antibiotics in veterinary practice is a special danger for the development of antibiotic resistance. The problem of public health, human and veterinary is the acquired resistance of bacteria to antibiotics. Of particular importance is the emergence of multidrug resistance to Escherichia coli, which is becoming more common in the world, both in human and veterinary medicine, and the possible transmission of resistant Escherichia coli between animals and humans. The purpose of this paper is to show the importance of the rational use of antibiotics in animals and humans to prevent the spread of antibiotic resistance. Escherichia coli is an intestinal bacterium of all mammals, widespread in the environment and often present in food of animal origin. Today, a pluripotent bacterium and a carrier of antibiotic resistance genes due to anthropogenic factors, and genes are transmitted through animal bacteria, food bacteria to bacteria of human origin

    Pathology of Heavy Metals Toxicity in Experimental Animal as Model Animals for Poisoning in Livestock

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    Pollution is a global problem that can cause health problems in organisms. Heavy metal pollutants from the environment can enter the body systems of animals and humans through the food chain. Several cases of severe poisoning in animals have been reported, especially in grazing animals around landfills and show pathological findings. This article aims to describe the gross pathological and histopathological abnormalities of heavy metal poisoning Arsenic (As), Cadmium (Cd), Copper (Cu), Mercury (Hg), Manganese (Mn) and Lead (Pb) which are focused in laboratory animals and chickens as animal models of poisoning in livestock as animal consumption. In general, the organs that are heavily affected by heavy metals are the liver, kidneys, testes, and ovaries. This article is expected to increase the knowledge of readers and practitioners in the examination differential diagnosis for the possibility of heavy metal poisoning which can be acute or chronic

    Application of Microsatellite Markers for Genetic Diversity Analysis of Indonesian Local Cattle

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    Animal genetic resources (AnGR), including cattle, have been valuable national assets that need to be preserved and developed. There are at least 16 recognized breeds of cattle that have been registered as local and new breeds by the Ministry of Agriculture of the Republic of Indonesia. Conservation and development programs of these local cattle breeds require basic information regarding their genetic diversity, relationships, and structures. There are several types of DNA markers that can be used for genetic diversity analysis, such as microsatellite markers. Microsatellites or short tandem repeats (STRs) are a group of DNA sequences consisting of tandemly repeated units (1–6 bp), which are abundant throughout the genome and can be found in both coding and non-coding regions. The primary advantages of microsatellites are that they are inherited in a Mendelian pattern (codominant markers), high polymorphism rates, and high abundances throughout the genome. The aim of this review is to discuss the application of microsatellite markers for genetic diversity analysis in Indonesian local cattle based on 3 indices: number alleles per locus, expected heterozygosity (He), and polymorphisms information content (PIC). There are at least 28 microsatellite markers that have been studied in Indonesian local cattle, with the number of alleles per locus ranging from 2 to 32, He values ranging from 0.100 to 0.985, and PIC values from 0.095 to 0.935. Based on the PIC values, several microsatellites are classified as highly informative, e.g. BM1824, ILST6, TGLA126, TGLA53, TGLA227, TGLA122, ETH225, INRA23, SPS113, SPS115, BM1818, CSSM66, ETH10, INRA005, INRA037, ETH185, HEL017, and ILSTS029. Therefore, these microsatellite markers can be potentially used for future genetic diversity analysis of other breeds of cattle

    Tolerant Saline Forage: Characteristic, Nutrient Content, Productivity and Cultivation

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    The area of saline land in Indonesia will continue to expand which are potential to be used for forage development. The usage of saline land has a limiting factor of high salt content, that affects the productivity and nutritional quality forage. Several saline-tolerant fodder plants, including Pennisetum notatum, Pennisetum hybrida, Pennisetum purpureum, Panicum maximum, Setaria sphacelata, and Cynodon plectostachyus, have the potential to be developed. Plants respond to salinity by decreasing morphological performance, transpiration, and stomata. The productivity and nutrient content of grass are influenced by salinity. Saline-tolerant forage have similar productivity and nutrient content to those grown on optimal land. Fertilization, soil media, and the use of saline tolerant varieties can all be used to grow saline tolerant grass

    The Role of Selenium in Controlling Reproductive Disorder in Beef Cattle

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    Reproductive failure is regarded as a problem in the breeding of beef cattle as indicated by low calving rate, low conception rate, longer periods of calving interval, and neonatal mortality. Selenium deficiency may lead to non-infectious reproduction disorder in ruminants. The purpose of this review is to evaluate the role of selenium in preventing reproduction failure of beef cattle. In the reproduction process, selenium is required for cellular respiration, cellular oxidation, DNA and RNA replication, the integrity of cells membrane, and releasing free radicals. Selenocysteine (SeCys) is the main component of selenoprotein consisting of glutathione peroxidase (GPX) to inhibit free radicals formation and reduce risks of tissue damage. Glutathione peroxidases (GPXs) involved are: GPX-1 (cytosolic), GPX-2 (gastrointestinal specific), GPX-3 (plasma/extracellular), GPX-4 (phospholipid-hydroperoxides/intracellular) and GPX-5 (spermatozoa mitochondrial capsule). Selenium as an antioxidant is potentially involved in reducing fertility, stillbirth, abortus, and premature in cows based on oxidative stress and selenium deficiency. In male cattle, the role of selenium is to maintain the integrity of cells membrane, spermatozoa fertility, and ejaculation. The selenium deficiency may therefore affect spermatozoa fertility, motility, and fusion to oocytes due to lipid peroxidation. It is then regarded as a factor in reproductive failure mainly in the infertility of cattle. Treatments for reproductive failure due to selenium deficiency could be conducted by supplementing selenium in the mineral mix, periodical dosing of selenium salt, and providing Se-mineral block,  the combination of selenium and vitamin E or selenium supplementation in soils to improve the quality of fodder and feeds

    Melioidosis: Important Neglected Zoonosis and Their Presence in Animal in Indonesia, Handling Constraints and Solutions

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    Melioidosis is a zoonosis caused by the bacterium Burkholderia pseudomallei, a saprophyte bacteria that is widely found in the environment. This bacteria causes Melioidosis in various animal species with clinical manifestations vary depending on species, but generally fever, depression, weight loss, respiratory sign, lameness, swelling of the joints, and potentially death. The incidence of Melioidosis in humans has been widely reported in many countries and it is estimated that every year there are 20,038 cases with a mortality rate of 51%. In contrary, there have not been many reports of Melioidosis in animals in the world, due to Melioidosis is not well known, limited diagnostic techniques and laboratory facilities in identifying the disease correctly. The presence of Melioidosis in animals and humans has been reported in Indonesia but the incidence is not yet known. This paper discusses Melioidosis in animals, etiological agent, epidemiology, modes of transmission, clinical manifestations, diagnosis and prevention and their presence in animals in Indonesia and constraints and solutions

    Challenging Efforts to Find African Swine Fever Vaccine

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    African swine fever (ASF) has been endemic in Indonesia and neighbouring countries. So far, the only reliable measure to eradicate the disease has been the application of strict biosecurity and culling of all infected pigs. This method is not feasible in Indonesia because most pig farms are small with a deficient level of biosecurity. Vaccination would be the most practical control measure, but no vaccine has been available for ASF. The difficulties encountered in developing the ASF vaccine lie in the fact that the ASF virus is very complex, with a sophisticated ability to paralyze the host immune system. ASF virus infects monocytes and macrophages, causing the cells to lose their functions to mount immune responses, further complicating vaccine development. Killed vaccines, even those containing complete structural and non-structural proteins of the virus and fortified with potent adjuvants for both humoral and cellular immune responses, were practically incapable of inducing protective immunity. Subunit vaccines containing recombinant viral proteins have also been developed, but none have provided satisfactory protection even though the vaccine indicates neutralizing antibodies. Live vaccines prepared from naturally low virulent viral strains or by repeated attenuation in cell cultures provided more satisfactory protective immunities than the inactive or subunit vaccines. However, their use in the field had caused severe side effects because the mutant still had residual virulence. Live vaccines prepared by deleting genes that play a role in virulence have been the most promising approach. Several mutants that were no longer virulent but capable of inducing protective immunity have been identified; however, lengthy safety testing is still needed before this vaccine is commercially available

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