Restructuring the knowledge production value chain in publishing

The current system of publishing (i.e. knowledge sharing) values individualism and commodification, restricting our use of existing knowledge. The Western model of knowledge production is not currently inclusive of other forms of knowledge, which inhibits the reuse, adaptation, reinterpretation and development of existing knowledge. The author proposes that knowledge systems be purposefully re-created to prioritize the end users’ needs and value them as co-creators

Transport analytics in action: a cloud-based decision support system for efficient city bus transportation

Optimising city bus transport operations helps conserve fuel by providing the urban transport service as efficiently as possible. This study develops a Cloud-based Decision Support System (C-DSS) for transport analytics. The C-DSS is based on an intelligent model on location of depots for opening new depots and/or closing a few existing depots and allocation of city-buses to depots. The C-DSS is built on the Cloud Computing architecture with three layers and includes an efficient and simple greedy heuristic algorithm. Using modern information and communications technology tools, the proposed C-DSS minimizes the cost of city bus transport operations and in turn to reduce fuel consumption and CO2 emissions in urban passenger transport. The proposed C-DSS is demonstrated for its workability and evaluated for its performance on 25 large scale pseudo data generated based on the observation from Bangalore Metropolitan Transport Corporation (BMTC) in India

Cellular mechanisms governing glucose-dependent insulinotropic polypeptide secretion.

Glucose-dependent insulinotropic polypeptide (GIP) is a gut hormone secreted from the upper small intestine, which plays an important physiological role in the control of glucose metabolism through its incretin action to enhance glucose-dependent insulin secretion. GIP has also been implicated in postprandial lipid homeostasis. GIP is secreted from enteroendocrine K-cells residing in the intestinal epithelium. K-cells sense a variety of components found in the gut lumen following food consumption, resulting in an increase in plasma GIP signal dependent on the nature and quantity of ingested nutrients. We review the evidence for an important role of sodium-coupled glucose uptake through SGLT1 for carbohydrate sensing, of free-fatty acid receptors FFAR1/FFAR4 and the monoacyl-glycerol sensing receptor GPR119 for lipid detection, of the calcium-sensing receptor CASR and GPR142 for protein sensing, and additional modulation by neurotransmitters such as somatostatin and galanin. These pathways have been identified through combinations of in vivo, in vitro and molecular approaches

Keeping children safe? Advancing social care assessments to address harmful sexual behaviour in schools

International evidence suggests that schools are locations where systems, practices and cultures can enable harmful sexual behaviours. However, in England, welfare assessments primarily used by statutory social services largely target young people and their families, with limited capacity to assess environments beyond the home. Where young people display harmful sexual behaviours within educational settings, social care systems are yet to assess the factors within schools which may accelerate risks associated with harmful sexual behaviours. This exploratory article presents evidence on the opportunities for school assessment using cumulative learning from two studies. The first investigated enablers and barriers to addressing harmful sexual behaviour in schools. The second employed the learning from the first through an action research study to develop school context assessments within a child protection system. Both studies employed a mixed-methods approach including observations, case review, focus groups, surveys and policy reviews to access data. Synthesised findings highlight: the value of exploring school contexts when assessing the nature of extra-familial abuse; the opportunities and challenges of utilising research methods for assessing school environments; and the role new assessment frameworks could play in supporting the inclusion of school contexts, and research methods, into welfare assessments of extra-familial abuse

Valuation impacts of environmental protection taxes and regulatory costs in heavy-polluting industries

In 2016, the issue of the Environmental Protection Tax Law indicated the enhancement of environmental protection in China. This study examines the market reaction to firms in heavy-polluting industries, and the effects of external legal institutional quality and internal environmental disclosure on firm value around the passage of Environmental Protection Tax Law. Using an event study approach coupled with ordinary least square regressions, the researchers find a significantly negative market reaction to firms in heavy-polluting industries, but this negative reaction varies depending on the expected increase in future regulatory costs. Specifically, the above negative reaction is stronger when the firm reveals that itself or its subsidiary belongs to heavy-polluting industry, however it would be mitigated when a firm is in a region with better quality of legal institutions or discloses environmental improvement activities. Overall, the results are consistent with the market perceiving that the environmental protection tax law enacted would increase regulatory costs for firms in heavy-polluting industries, and also show the higher-quality regional legal institutions and more efforts on environmental protection could relieve the market’s pessimism caused by uncertainty

Stress and wellbeing in prison officers

Prison officers are at greater risk of work-related stress than most other occupations in the UK (Johnson, et al, 2005). The rates of mental health problems and burnout in the profession are also comparatively high (Kinman et al., 2016; Kunst, 2011). Challenges to the wellbeing of prison staff include heavy workloads, lack of autonomy and support, low resources, role stressors and exposure to aggression and violence (Finney et al,. 2013).  In this chapter we draw on research conducted by ourselves and others that identifies the key stressors experienced by UK prison officers and the implications for their wellbeing and job performance. Particular focus is placed on our research that has utilised the Health and Safety Executive Management Standards framework to diagnose the psychosocial hazards experienced by prison staff, but other stressors, such as personal experiences of aggression and violence, poor recovery opportunities and presenteeism, are also considered.  We argue that carefully targeted, multi-level interventions are needed to address the challenges faced by the sector and identify priorities for future research

Between copyright and creativity: Edison’s kinetoscope and technological innovations in optical printing

Focusing on Edison’s early cinematic apparatus and the optical printer, this chapter explores how copyright law intersects with creativity, providing an alternative to teleological accounts of moving-image technologies. Thomas Edison attempted to control the film industry through patents and copyright. Edison’s first film experiments were registered as a series of photographs on card by his assistant, W. L. Dickson. In protecting these contact copies as paper prints with copyright, the new medium of motion pictures was being formalized. The necessity to duplicate film to support the development of exhibition and distribution was also necessary for copyright purposes. An archaeological approach is utilized to explore how paper prints enabled innovation in the area of the optical printer, a primary form of duplication in cinema. In developing approaches that could bring to life the remaining examples of early cinema, novel solutions in the form of innovations were required. The overlapping concerns of the copyright clerk, the film entrepreneur, and the film historian thus provide a basis for new materials and new innovations in moving-image technology and film history

Establishing an optimized method for the separation of low and high abundance blood plasma proteins

The study tested the efficiency and reproducibility of a method for optimal separation of low and high abundant proteins in blood plasma. Firstly, three methods for the separation and concentration of eluted (E: low abundance), or bound (B: high abundance) proteins were investigated: TCA protein precipitation, the ReadyPrep™ 2-D cleanup Kit and Vivaspin Turbo 4, 5 kDa ultrafiltration units. Secondly, the efficiency and reproducibility of a Seppro column or a ProteoExtract Albumin/IgG column were assessed by quantification of E and B proteins. Thirdly, the efficiency of two elution buffers, containing either 25% or 10% glycerol for elution of the bound protein, was assessed by measuring the remaining eluted volume and the final protein concentration. Compared to the samples treated with TCA protein precipitation and the ReadyPrep™ 2-D cleanup Kit, the E and B proteins concentrated by the Vivaspin4, 5 kDa ultrafiltration unit were separated well in both 1-D and 2-D gels. The depletion efficiency of abundant protein in the Seppro column was reduced after 15 cycles of sample processing and regeneration and the average ratio of E/(B + E) × 100% was 37 ± 11(%) with a poor sample reproducibility as shown by a high coefficient of variation (CV = 30%). However, when the ProteoExtract Albumin/IgG column was used, the ratio of E/(B + E) × 100% was 43 ± 3.1% (n = 6) and its CV was 7.1%, showing good reproducibility. Furthermore, the elution buffer containing 10% (w/v) glycerol increased the rate of B protein elution from the ProteoExtract Albumin/IgG column, and an appropriate protein concentration (3.5 µg/µl) for a 2-D gel assay could also be obtained when it was concentrated with Vivaspin Turbo 4, 5 kDa ultrafiltration unit. In conclusion, the ProteoExtract Albumin/IgG column shows good reproducibility of preparation of low and high abundance blood plasma proteins when using the elution buffer containing 10% (w/v) glycerol. The optimized method of preparation of low/high abundance plasma proteins was when plasma was eluted through a ProteoExtract Albumin/IgG removal column, the column was further washed with elution buffer containing 10% glycerol. The first and second elution containing the low and high abundance plasma proteins, respectively, were further concentrated using Vivaspin® Turbo 4, 5 kDa ultrafiltration units for 1 or 2-D gel electrophoresis

Interwar women's comic fiction: 'have women a sense of humour?'

This collection of essays examines the work of five intermodernist writers. Some were established authors before the First World War and others continued to write after the Second World War, but this book focuses particularly on their writing between 1918 and 1939. Stella Benson, Bradda Field, Ivy Compton-Burnett, Stella Gibbons and Winifred Watson had much in common: they all wrote novels full of comic moments, which often challenged the cultural politics of the interwar period. Drawing on the literary and critical contexts of each novel, the essays here discuss the use of comic structures that enabled the authors to critique the dominant patriarchal structures of their time, and offer an alternative, sometimes subversive, view of the world in which their characters reside. This book contributes to the growing scholarly interest in interwar fiction, focusing principally on novelists who have fallen out of public view. It widens our understanding both of the authors and of the continuing, highly topical debate about interwar women novelists

Point OutWords: protocol for a feasibility randomised controlled trial of a motor skills intervention to promote communicative development in non-verbal children with autism

Background: Point OutWords is a caregiver-delivered, iPad-assisted intervention for non-verbal or minimally verbal children with autism. It aims to develop prerequisite skills for communication such as manual and oral motor skills, sequencing, and symbolic representation. This feasibility trial aims to determine the viability of evaluating the clinical efficacy of Point OutWords. Methodology: We aim to recruit 46 non-verbal or minimally verbal children with autism and their families, approximately 23 per arm. Children in the intervention group will use Point OutWords for half an hour, five times a week, for 8 weeks. Children in the control group will have equal caregiver-led contact time with the iPad using a selection of control apps (e.g. sensory apps, drawing apps). Communication, motor, and daily living skills are assessed at baseline and post-intervention. Parents will keep diaries during the intervention period and will take part in focus groups when the intervention is completed. Discussion: Point OutWords was developed in collaboration with children with autism and their caregivers, to provide an intervention for a subgroup of autism that has been historically underserved. As autism is a heterogeneous condition, it is unlikely that one style of intervention will address all aspects of its symptomatology; the motor skills approach of Point OutWords can complement other therapies that address core autistic symptoms of social cognition and communication more directly. The current feasibility trial can inform the selection of outcome measures and design for future full-scale randomised controlled trials of Point OutWords and of other early interventions in autism. Trial registration: ISRCTN, ISRCTN12808402. Prospectively registered on 12 March 2019. Keywords: Autism spectrum disorder, Minimally verbal, Non-verbal, Motor, Language, Communication, iPad, Feasibility, Randomised controlled tria