Sounds Accessible:Envisioning Accessible Audio Media Futures with People with Aphasia

Audio-media, such as radio and podcasts, are a vital means to engage with global events, access education, or offer entertainment. However, for people with complex communication needs, such as aphasia, there can be accessibility challenges. While accessibility research has largely focused on audiovisual media, little work has considered audio-media, particularly for users with complex communication needs. To address this gap, we undertook six co-design workshops with 10 people with aphasia to re-imagine access to audio-media. We uncover how our co-designers perceive audio-media as more than a tool, but a part of daily intimacies; shaping social relationships and contributing to therapeutic recovery. Through a Research-through-Design process culminating in one low-fidelity and three high-fidelity technology probes that embody novel accessibility interventions, our findings further challenge conventional approaches to audio-media accessibility and signal new directions for future design

Prospective Associations Between Structural Brain Development and Onset of Depressive Disorder During Adolescence and Emerging Adulthood

OBJECTIVE: Brain structural alterations are consistently reported in depressive disorders, yet it remains unclear whether these alterations exist prior to disorder onset and thus may reflect a preexisting vulnerability. The authors investigated prospective adolescent neurodevelopmental risk markers for depressive disorder onset, using data from a 15-year longitudinal study.METHODS: A community sample of 161 adolescents participated in neuroimaging assessments conducted during early (age 12), mid (age 16), and late (age 19) adolescence. Onsets of depressive disorders were assessed for the period spanning early adolescence through emerging adulthood (ages 12-27). Forty-six participants (28 female) experienced a first episode of a depressive disorder during the follow-up period; 83 participants (36 female) received no mental disorder diagnosis. Joint modeling was used to investigate whether brain structure (subcortical volume, cortical thickness, and surface area) or age-related changes in brain structure were associated with the risk of depressive disorder onset.RESULTS: Age-related increases in amygdala volume (hazard ratio=3.01), and more positive age-related changes (i.e., greater thickening or attenuated thinning) of temporal (parahippocampal gyrus, hazard ratio=3.73; fusiform gyrus, hazard ratio=4.14), insula (hazard ratio=4.49), and occipital (lingual gyrus, hazard ratio=4.19) regions were statistically significantly associated with the onset of depressive disorder.CONCLUSIONS: Relative increases in amygdala volume and temporal, insula, and occipital cortical thickness across adolescence may reflect disturbances in brain development, contributing to depression onset. This raises the possibility that prior findings of reduced gray matter in clinically depressed individuals instead reflect alterations that are caused by disorder-related factors after onset.</p

Pressure and Praise as an Action Research Methodology:The Case of Fairwork

In platform-mediated sectors such as ride-hailing, delivery, care work and cloudwork, gig workers often lack essential employment protections such as minimum wage and social security. Misclassification of workers, opaque algorithms, exploitation of legal loopholes and lobbying by platforms against protective legislation further exacerbates inequalities and discrimination. The Fairwork project at the University of Oxford and WZB Berlin, in collaboration with a global network of partners, aims to improve conditions in the platform economy through action research. Using a principles-based framework, the project evaluates and scores platforms against universal standards of fairness – fair pay, fair conditions, fair contracts, fair management and fair representation. The action-research methodology combines data triangulation and stakeholder engagement to ensure platform evaluations are objective and impartial, while seeking to hold platforms accountable and advocating for better labour standards in the gig economy. This article explores Fairwork as an action research methodology that has established positive feedback loops, driving platforms towards pro-worker policy changes. We hope this discussion encourages other politically engaged social scientists to adopt action research approaches in their own work.</p

<i>B</i>₀ navigator enables respiratory motion navigation in radial stack-of-stars liver Look-Locker <i>T</i>₁ mapping

Purpose: To develop a B0 self-navigation approach to estimate respiratory motion for motion-corrected liver T1 mapping using a Look-Locker acquisition with radial stack-of-stars trajectory. Methods: The proposed method derives 1D field-map profiles from the oversampled k-space center to estimate a normalized breathing curve and the B0 variation amplitude for each slice and coil. B0 drift and contrast variations, inherent to the Look-Locker acquisition, were modeled and corrected by fitting and demodulating drift and offset terms. The breathing curve was employed to bin data into motion states for motion-resolved reconstruction, followed by water-specific T1 mapping. Simulations with an anatomical body model and in vivo experiments with a Look-Locker multi-echo gradient echo sequence were performed to validate the technique. The estimated normalized breathing curve was compared with magnitude- and phase-based self-navigation approaches using principal component analysis. Results: The proposed B0 self-navigation reliably estimated the normalized breathing curve and the B0 variation amplitude in simulations and in vivo. B0 variation amplitudes increased with greater tissue displacement, with median values across slices and coils ranging from 4 to 15 Hz at 3 T in volunteers. Motion-resolved reconstruction using the estimated breathing curve reduced motion artifacts and improved image and T1 mapping quality compared to motion-averaged reconstruction. Conclusion: B0 self-navigation allows estimation of respiratory motion in acquisitions with varying contrast and quantifies the B0 variation amplitude, providing a possible surrogate signal for tissue displacement and enabling self-gated liver T1 mapping using a Look-Locker approach.</p

Characterization of Portable Ultra-Low Field MRI Scanners for Multi-Center Structural Neuroimaging

The lower infrastructure requirements of portable ultra-low field MRI (ULF-MRI) systems have enabled their use in diverse settings such as intensive care units and remote medical facilities. The UNITY Project is an international neuroimaging network harnessing this technology, deploying portable ULF-MRI systems globally to expand access to MRI for studies into brain development. Given the wide range of environments where ULF-MRI systems may operate, there are external factors that might influence image quality. This work aims to introduce the quality control (QC) framework used by the UNITY Project to investigate how robust the systems are and how QC metrics compare between sites and over time. We present a QC framework using a commercially available phantom, scanned with 64 mT portable MRI systems at 17 sites across 12 countries on four continents. Using automated, open-source analysis tools, we quantify signal-to-noise, image contrast, and geometric distortions. Our results demonstrated that the image quality is robust to the varying operational environment, for example, electromagnetic noise interference and temperature. The Larmor frequency was significantly correlated to room temperature, as was image noise and contrast. Image distortions were less than 2.5 mm, with high robustness over time. Similar to studies at higher field, we found that changes in pulse sequence parameters from software updates had an impact on QC metrics. This study demonstrates that portable ULF-MRI systems can be deployed in a variety of environments for multi-center neuroimaging studies and produce robust results.</p

Structural and functional studies of the VAPB-PTPIP51 ER-mitochondria tethering proteins in neurodegenerative diseases

Signaling between the endoplasmic reticulum (ER) and mitochondria regulates many of the seemingly disparate physiological functions that are damaged in neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). A number of studies have now demonstrated that ER-mitochondria signaling is perturbed in these diseases and there is evidence that this may be a driving mechanism in disease onset and progression. VAPB and PTPIP51 are ER-mitochondria tethering proteins; VAPB is an ER protein and PTPIP51 is an outer mitochondrial membrane protein and the two proteins interact to enable inter-organelle signaling. The VAPB-PTPIP51 interaction is disrupted in Alzheimer's disease, Parkinson's disease, FTD and ALS. Here we review the roles of VAPB and PTPIP51 in ER-mitochondria signaling and the mechanisms by which neurodegenerative disease insults may disrupt the VAPB-PTPIP51 interaction.</p

Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease

Depression is a risk factor for the later development of Alzheimer’s disease (AD), but evidence for the genetic relationship is mixed. Assessing depression symptom-specific genetic associations may better clarify this relationship. To address this, we conducted genome-wide meta-analysis (a genome-wide association study, GWAS) of the nine depression symptom items, plus their sum score, on the Patient Health Questionnaire (PHQ-9) (GWAS-equivalent N: 224,535–308,421) using data from UK Biobank, the GLAD study and PROTECT, identifying 37 genomic risk loci. Using six AD GWASs with varying proportions of clinical and proxy (family history) case ascertainment, we identified 20 significant genetic correlations with depression/depression symptoms. However, only one of these was identified with a clinical AD GWAS. Local genetic correlations were detected in 14 regions. No statistical colocalization was identified in these regions. However, the region of the transmembrane protein 106B gene (TMEM106B) showed colocalization between multiple depression phenotypes and both clinical-only and clinical + proxy AD. Mendelian randomization and polygenic risk score analyses did not yield significant results after multiple testing correction in either direction. Our findings do not demonstrate a causal role of depression/depression symptoms on AD and suggest that previous evidence of genetic overlap between depression and AD may be driven by the inclusion of family history-based proxy cases/controls. However, colocalization at TMEM106B warrants further investigation.</p

Export channel choice for SMEs: a cognitive perspective

Despite decades of research on SME export channel choice, we know little about the role played by managerial mindsets. Managerial mindsets are the cognitive mental models managers rely on for processing and evaluating information and making decisions. In this paper, we develop and test the notion that, in addition to the influence of transaction cost factors, the global mindset of top managers has a significant impact on the export channels that SMEs use. We also suggest that this relation is sensitive to the level of political instability in the target market since such instability increases risk and uncertainty. A multinomial regression analysis was used to analyze the responses of a sample of 208 Chinese SMEs. The results provide support for our ideas. In this way, we contribute to a better understanding of how managerial thinking can influence the strategic choices that are made and the boundary conditions that exist when SMEs expand abroad.</p