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    23702 research outputs found

    What can I learn from students?

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    Redefining Social Innovation to Include Categories

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    Insights

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    Can Design Methods for Social Innovation Improve Smart Cities?

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    Embracing Inclusivity in Design

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    Achieving Culturally Inclusive Design for Social Innovation in Indigenous Communities

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    The Dog that Doesn't Bark: Federal Regulation of Industrial Air Pollution in Canada

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    In a well-known Sherlock Holmes story, Holmes solved a murder mystery by pointing to the [“curious incident of the dog in the night-time”](https://brieflywriting.com/2012/07/25/the-dog-that-didnt-bark-what-we-can-learn-from-sir-arthur-conan-doyle-about-using-the-absence-of-expected-facts/). “The dog did nothing in the night-time”, countered the Scotland Yard detective on the case. “That was the curious incident” replied Holmes. [Health Canada](https://www.canada.ca/en/health-canada/services/publications/healthy-living/2021-health-effects-indoor-air-pollution.html) estimates that air pollution accounts for 15,300 premature deaths annually in Canada. All the key air pollutants are found on Canada’s [list of toxic substances](https://www.canada.ca/en/environment-climate-change/services/canadian-environmental-protection-act-registry/substances-list/toxic.html), giving Environment and Climate Change Canada (ECCC) full authority to regulate emissions. And yet there are only a handful of federal regulations addressing air pollution from industrial/stationary sources. This case study addresses the question – why doesn’t the dog bark

    HER2 breast cancer biomarker detection using a sandwich optical fiber assay

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    Optical fiber-based surface plasmon resonance (OF-SPR) sensors have demonstrated high versatility and performances over the last years, which propelled the technique to the heart of numerous and original biosensing concepts. In this work, we contribute to this effort and present our recent findings about the detection of breast cancer HER2 biomarkers through OF-SPR optrodes. 1 cm-long sections of 400 μm core-diameter optical fibers were covered with a sputtered gold film, yielding enhanced sensitivity to surface refractive index changes. Studying the impacts of the gold film thickness on the plasmonic spectral response, we improved the quality and reproducibility of the sensors. These achievements were correlated in two ways, using both the central wavelengths of the plasmon resonance and its influence on the bulk refractive index sensitivity. Our dataset was fed by additional biosensing experiments with a direct and indirect approach, relying on aptamers and antibodies specifically implemented in a sandwich layout. HER2 biomarkers were specifically detected at 0.6 μg/mL (5.16 nM) in label-free while the amplification with HER2-antibodies provided a nearly hundredfold signal magnification, reaching 9.3 ng/mL (77.4 pM). We believe that these results harbinger the way for their further use in biomedical samples

    How Indigenous Knowledge and Worldviews Can Help Inform Design for Social Innovation

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    The influence of carbide formation in ferrite on the bainitic type transformation

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    The effect of carbide formation on the development of the bainitic type transformation was studied using phase field modeling. The phase field model incorporated the displacive structural transformation producing a misfitting product phase, long range elastic interactions, carbon partitioning from austenite and ferrite and the formation of carbides in ferrite modelled as carbon sinks. The results of the simulations performed for the systems with different carbide nucleation sequences demonstrate that initially, due to a slow nucleation of carbides and fast carbon partitioning, carbon diffusion to austenite was the dominant process leading to the decrease in the transformation rate. However, after some period of time, the effect of carbon depletion in the solid solution by carbides became more significant, which led to the reduction of the average concentration of carbon in the whole system and the acceleration of the structural transformation. The rate of carbide nucleation and the number of nucleated carbides controlled both the transformation rate and the period of time before the transformation acceleration

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