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Adherence to the Mediterranean dietary approaches to stop hypertension intervention for neurodegenerative delay (MIND) diet and trajectories of depressive symptomatology in youth
Background: The rising prevalence of youth depression underscores the need to identify modifiable factors for prevention and intervention. This study aims to investigate the protective role of Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet on depressive symptoms in adolescents.
Methods: Participants were identified from the Adolescent Brain Cognitive Development study. Adherence to the MIND diet was measured by the Child Nutrition Assessment or the Block Kids Food Screener. Depressive symptoms were measured annually using the Child Behavior Checklist's depression subscale. We utilized regression analyses and cross-lagged panel modeling (CLPM) to examine longitudinal associations. Additional analyses adjusted for polygenic risk scores for depression, and changes in Body Mass Index (BMI) and waist-to-height ratio.
Results: Of the 8459 children (52.3 % male; mean age 10.9 [SD, 0.6] years), 2338 (27.6 %) demonstrated high MIND diet adherence, while 2120 (25.1 %) showed low adherence. High adherence was prospectively associated with reduced depressive symptoms (adjusted β, −0.64, 95 % CI, −0.73 to −0.55; p < 0.001) and 46 % lower odds of clinically relevant depression (adjusted odds ratio, 0.54, 95 % CI, 0.39 to 0.75; p < 0.001) at two-year follow-up. CLPM analyses showed significant cross-lag paths from MIND diet scores to less depressive symptoms across three time points. These associations persisted independently of changes in BMI and waist-to-height ratios, and were not significantly moderated by genetic predisposition to depression.
Conclusions: Higher adherence to the MIND dietary pattern was longitudinally associated with decreased risk of depressive symptoms in adolescents. Promoting MIND diet may represent a promising strategy for depression prevention in adolescent populations
Update to the PRISMA guidelines for network meta-analyses and scoping reviews and development of guidelines for rapid reviews: a study protocol for a scoping review
Objective: The objective of this scoping review is to develop a list of items for potential inclusion in the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) reporting guidelines for network meta-analysis (NMA), scoping reviews (ScRs), and rapid reviews (RRs).
Introduction: The PRISMA extensions for NMA and ScRs were published in 2015 and 2018. However, since then, their methodologies and innovations, including automation, have evolved. There is no reporting guideline for RRs. In 2020, an updated PRISMA statement was published, reflecting advances in the conduct and reporting of systematic reviews. These advances are not yet incorporated into these PRISMA extensions. We will update our previous methods scoping reviews to inform the update of PRISMA-NMA and PRISMA-ScR as well as the development of the PRISMA-RR reporting guidelines.
Inclusion criteria: This review will include any study designs evaluating the completeness of reporting, or offering reporting guidance, or assessing methods relevant to NMA, ScRs, or RRs. Editorial guidelines and tutorials that describe items related to reporting completeness will also be eligible.
Methods: We will follow the JBI guidance for scoping reviews. For each PRISMA extension, we will (1) search multiple electronic databases from inception, (2) search for unpublished studies, and (3) scan the reference lists of included studies. There will be no language limitations. Screening and data extraction will be conducted by 2 researchers independently. A third researcher will resolve discrepancies. We will conduct frequency analyses of the identified items. The final list of items will be considered for potential inclusion in the relevant PRISMA reporting guidelines.
Review registration: NMA protocol (OSF: https://doi.org/10.17605/OSF.IO/7BKWY); ScR protocol (OSF: https://doi.org/10.17605/OSF.IO/MTA4P); RR protocol (OSF: https://doi.org/10.17605/OSF.IO/3JCPE); EQUATOR registration link: https://www.equator-network.org/library/reporting-guidelines-under-development/reporting-guidelines-under-development-for-systematic-reviews
Spontaneous resolution of the Fe(C2O4)3 anion and inclusion of chiral guest molecules in BEDT-TTF radical-cation salts
Dominance of leading business schools in top journals: Insights for increasing institutional representation
The competitive push for business schools to publish in prestigious journals has resulted in a disproportionate number of papers in prestigious Management and Operations Research/Management Science (OR/MS) journals coming from a select group of institutions. Our analysis shows the Matthew effect of prestigious journals favors established schools with 51.2 % of papers in 18 Management ABS 4* journals and 61.3 % of papers in 3 OR/MS ABS 4* journals involving authors from the 100 top business schools identified by the University of Texas at Dallas (UTD). Citation patterns are similarly concentrated among papers authored by scholars from UTD-listed business schools, with nearly 80 % of citations from 4* Management journals directed to equally rated 4* Management journals (67.8 % for 4* OR/MS journals). An initial regression analysis suggested a positive correlation between the percentage of papers in a journal attributed to authors affiliated with those leading business schools and journal citation performance. However, further examination using multi-level regression adjusted for journal prestige, using the ABS and FT50 lists, showed a negative interaction effect on citation rates for papers from these schools in prestigious OR/MS journals. This insightful finding was confirmed by a post-hoc comparison revealing no significant citation advantage in prestigious journals for papers from leading business schools over those from a broader range of institutions. Thus, while leading business schools benefit from disproportionate space in prestigious journals, this does not translate to a citation advantage for the journals themselves, indicating no Matthew effect at the journal level driven by these schools. We argue that our findings show a unique opportunity for prestigious journals and business schools to expand collaborations with institutions in geographies historically underrepresented without a significant impact on the citation performance of those journals. This inclusion would only benefit research excellence, as our results demonstrate convergence in citation rates, citation patterns on external research areas, and topics across both subsets of papers—from leading institutions and those from a broader institutional spectrum—published in prestigious journals, indicating that diversifying contributions does not compromise the performance of these journals
Barriers to teaching and research provision in the UK Higher Education sector during the Covid-19 pandemic
The outbreak of the Covid-19 pandemic necessitated a rapid transition to remote teaching in Higher Education (HE) institutions worldwide. While there is existing research on the advantages and disadvantages of online teaching from transactional and adult learning theory perspectives, there is a lack of investigation into the specific challenges faced by academics in the UK HE sector concerning their teaching and research during the pandemic. This paper aims to fill this research gap by examining the experiences of nearly 300 academics in the UK HE sector through a qualitative online questionnaire. The findings of this study reveal several challenges associated with the sudden shift to online teaching. These challenges include time constraints, a lack of digital skills, technology issues, and an increased teaching workload. Academics also encountered difficulties engaging and connecting with students, as remote teaching created a sense of detachment between them. This finding aligns with the theoretical propositions of the self-determination theory, particularly regarding the sense of relatedness. Remote teaching presented obstacles in gauging students' reactions and understanding, as it lacked interactivity, personalisation, and the ability to keep students motivated and engaged. Additionally, academics faced issues assessing online assignments and monitoring students' progress and development. The isolation from remote work further contributed to a lack of concentration in teaching and research. The study also highlights the significant increase in teaching loads experienced by academics, as they had to adapt their teaching materials to suit the new mode of delivery. Academic research was impeded by limited access to labs, equipment, research time, and support due to the demands of teaching. Field-based research was put on hold, and many academics found collaborating with colleagues without physical proximity challenging. Considering these challenges, the study proposes ideas for overcoming barriers in future crisis events. The findings have implications for research and policy, further discussed in the paper
The role of big data in public sector accounting and budgeting practices: evidence from a pandemic environment of an emerging economy
This paper investigates the actual and potential application of big data in the public sector accounting and budgeting practices in terms of enhancing accountability and openness in the public sector within the emerging economy of Sri Lanka during the COVID-19 pandemic. This research adopted hybrid ethnographic methodology by implementing data triangulation, where multiple datasets from various platforms were combined and analysed. The datasets were combined and analysed using thematic and summative content analyses. Big data use in the public sector could improve both accounting and budgeting practices in developing economies, especially when meeting challenges in a post-COVID-19 era. However, the political culture and the lack of awareness in big data utilisation have been barriers for big data applications. This research offers insights into policy reforms, especially concerning public sector accounting and budgeting practices, for the application of big data
Sex differences in gross motor competence in Italian children aged 3–11 years: a large-scale cross-sectional study
Background/Objectives: In recent years, there has been a significant increase in studies examining motor learning during preschool age and the early years of primary school. This study aimed to investigate sex differences in gross motor competence among Italian children aged 3–11 years.
Methods: A convenience sample of 8500 children (mean age = 8.37 years, SD = 1.98; 50% female) was included in this cross-sectional study. Gross motor skills were assessed using the Italian version of the Test of Gross Motor Development–3, which evaluates locomotion and ball control skills. A Linear Mixed Model was applied to examine the interaction between sex and age, with school included as a random intercept and BMI as a covariate.
Results: The results revealed a consistent trend of boys achieving significantly higher total scores for global motor competence (p < 0.001) across all age groups, except at age 11. Boys also demonstrated superior performance in ball control skills (p < 0.005) at all ages. In contrast, no significant differences were observed for locomotion skills overall. However, girls outperform boys in locomotor skills at ages 6, 7, and 8 (p < 0.001), with this trend disappearing by age 9. #
Conclusions: These findings highlight important sex-related differences in gross motor development during childhood, influenced by both biological and environmental factors. The results underscore the need for targeted interventions in educational settings to provide equitable opportunities for motor skill development, particularly for girls. Enhancing the quality of physical education and addressing gender disparities can support the acquisition of essential motor skills and promote lifelong physical activity
Carnosinase inhibition enhances reactive species scavenging in high fat diet
Aims: Life expectancy is typically reduced by 2-4 years in people with a body mass index (BMI) of 30-35 kg/m2 and by 8-10 years in people with a BMI of 40-50 kg/m2. Obesity is also associated with onset, or exacerbation of, multiple chronic diseases. Mechanistically, this, in part, involves formation of advanced glycation and lipidation end-products that directly bond with proteins, lipids, or DNA, thereby perturbing typical cellular function. Here we seek to prevent these damaging adduction events through inhibition of carnosinase enzymes that rapidly degrade the physiological reactive species scavenger, carnosine, in the body.
Main methods: Herein we performed in silico computational modelling of a compound library of ~53,000 molecules to identify carnosine-like molecules with intrinsic resistance to carnosinase turnover.
Key findings: We show that leading candidate molecules reduced reactive species in C2C12 myotubes, and that mice fed N-methyl-[6-(2-furyl)pyrid-3-yl]methylamine alongside a high fat diet had significantly decreased amounts of damaging plasma 4-hydroxynonenal and 3-nitrotyrosine reactive species. Oral administration of N-methyl-[6-(2-furyl)pyrid-3-yl]methylamine to high fat-fed mice also resulted in a modest ~10 % reduction in weight gain when compared to mice fed only high fat diet.
Significance: Our findings suggest that inhibition of carnosinase enzymes can increase the life-span, and thereby enhance the efficacy, of endogenous carnosine in vivo, thereby offering potential therapeutic benefits against obesity and other cardiometabolic diseases characterised by metabolic stress
Organisational career growth and work engagement: a moderated mediated model
Purpose – Drawing from the Conservation of Resources Theory and Organisational Justice Theory, this study examined the direct and indirect (via career resilience) effects of organisational career growth on work engagement. We further examined the boundary condition of procedure justice in the relationship between organisational career growth, career resilience, and work engagement.
Design/methodology/approach – We employed time-lagged data collected in three waves from 431 employees working in the public health sector. Hierarchical regression analysis and Hayes Process Macro were used to test the study hypotheses.
Findings – The findings revealed that organisational career growth has a significant positive direct and indirect influence on work engagement in the presence of career resilience. Also, the boundary condition of procedural justice was significant for employees who perceived procedural justice to be high as opposed to low.
Practical implications – Organisational career growth has a positive influence on employee work engagement. Therefore, public health organisations need to prioritise employee career growth by creating an enabling environment that will help employees' career prospects and mitigate employees’ perception of low procedural justice.
Originality/value – The originality of this study is in empirically establishing career resilience as an underlying mechanism in the relationship between organisational career growth and work engagement while considering the interactive effect of procedural justice. Additionally, the originality of this paper is demonstrated by empirically establishing that a perceived high level of procedural justice helps healthcare employees improve their work engagement, thus deepening our understanding of work engagement amongst health professionals