Ribosome Stalling Increases Sup35 Prion Conversion in Saccharomyces cerevisiae

Proteins are one of the four main macromolecules essential to life. They are responsible for a diverse array of processes, including cellular signaling, cell structure, and catalytic activity. These functions are directly related to the protein’s specific structure. Consequently, the misfolding of a protein, which can be due to a variety of factors, can lead to an alteration in the function of that protein. Misfolded proteins can also associate together to form aggregates, which can become toxic to cells. In prions and prion-like proteins, the misfolding of one protein can propagate to another protein, increasing aggregation, which can lead to cellular death and result in neurodegenerative diseases in mammals. One factor that is linked to increased misfolding is stalling of the ribosome, the cellular machinery responsible for the construction of proteins, during synthesis. In the model organism Saccharomyces cerevisiae, stalling is a natural process that may allow for misfolding to occur in a way that benefits yeast in times of stress. By integrating amino acids sequences known to stall ribosomes into a gene construct including the sequence of the known yeast prion Sup35, the mechanism and frequency at which ribosome stalling influences prion conversion can be investigated. We here demonstrate that ribosome stalling increases the frequency of Sup35 prion conversion when ribosomes are paused using known stalling sequences

The Grizzly, February 20, 2025

Sigma Gamma Rho: Semester of Service • The UC Tonight Modern Band • BearShare Now Open! • After the Career Fair: Checklist • Bird is the Word! • El Gordo Bros: Adding Flavor to Collegeville • Opinions: Bear-Bones • Ursinus Swimming Set for Championships! • A Wonderful Weekend of Sports: February 15-16thhttps://digitalcommons.ursinus.edu/grizzlynews/2047/thumbnail.jp

The Grizzly, February 27, 2025

The Fateful Fire of Elliott House • Mother Mold: A Cosmogony • Couldn\u27t Have Been an Email • Grubhub: Convenience or Chaos? • Opinions: Where Are My Fabulous Friends? • Bears Going to Battle: Men\u27s Wrestling • Bears\u27 Basketball Squads Make Conference Playoffshttps://digitalcommons.ursinus.edu/grizzlynews/2048/thumbnail.jp

Passport to Education: A Financial Guide to Studying Abroad | Grizzly Guide Webinar | Paula Álvarez & Marlie Derstine

Paula Álvarez is the Director of International Programs at Ursinus College and Marlie Derstine is a Study Abroad and International Student Advisor. On this webinar, we discuss the financial implications students may face when they study abroad, as well as how political and economic factors may affect their study abroad experience. Paula and Marlie also help us understand the nuances and details of study abroad, such as insurance, housing, and how study abroad is funded.https://digitalcommons.ursinus.edu/grizzly_wealth_webinar/1014/thumbnail.jp

Bodybuilding and Budgeting: A Check-In with Julian Smith | Grizzly Guide Webinar | Julian Smith

Julian Smith is a Quality Assurance Specialist and an IFBB Pro Bodybuilder. On this webinar, we catch up with Julian to discuss the changes to his financial situation since our first conversation. We discuss some of the behavioral changes he’s made that have allowed him to make the most of his finances while also being able to start his investing journey. We also discuss topics in personal finance, behavioral finance, and financial planning. Please see the following links for additional information: • 401(k) Hardship withdrawals • HSA detailshttps://digitalcommons.ursinus.edu/grizzly_wealth_webinar/1013/thumbnail.jp

Untitled Book Stack

This book stack was created by a first-year student at Ursinus College participating in a Common Intellectual Experience event. After a group Stacks on Stacks activity in Fall 2024, students were invited to submit their own individual creations in Spring 2025.https://digitalcommons.ursinus.edu/cie_stacks/1039/thumbnail.jp

The Grizzly, February 13, 2025

The Launch of Soulful Creations • Annual UC Career Fair Coming Soon! • CIE Syllabus Change Proposals • Professor Pairs • Behind Their Doors: Meet the New Staff of Ursinus • Valentine\u27s Day: Friend or Foe? • Shattering Limits: Bears Break School Records • Basketball Bears Push Towards Playoffs!https://digitalcommons.ursinus.edu/grizzlynews/2046/thumbnail.jp

The Grizzly, March 6, 2025

Bears\u27 Basketball Season Comes to an End • Tidbits About Title IX • Bears Together Strong • Saher on the Modern Rainbow Scare • Fundamentals • Opinions: Ranking Dining Options on Campus • Gymnastics Looks to Finish Strong! • Women\u27s Wrestling Ready to Rumblehttps://digitalcommons.ursinus.edu/grizzlynews/2049/thumbnail.jp

Childhood Recollection

This book stack was created by a first-year student at Ursinus College participating in a Common Intellectual Experience event. After a group Stacks on Stacks activity in Fall 2024, students were invited to submit their own individual creations in Spring 2025.https://digitalcommons.ursinus.edu/cie_stacks/1038/thumbnail.jp

Causes of Voter Wait Times During the 2022 U.S. Midterm Elections

Voter wait times have been an enduring issue in American Elections, with significant variation across individuals, voting precincts, and states. Past research has found that waiting in lines at the polls negatively impacts future voter turnout and public confidence in voting institutions. Additionally, a racial gap in voter wait times and resource allocation has been found in numerous studies that implies serious issues with the equality of our elections. The exact causes of the racial gap and voter wait times in general are still somewhat unclear, but prior work has considered as causes the allocation of voting resources, the procedural aspects of voting, as well as other non-structural issues. This study investigates the causes of voter wait times, with a specific focus on the role of wealth versus racial make-up of districts. Using several regression analyses on a combined dataset from the CCES, SPAE, and the U.S. Census, I examine the role of different causes of voter wait times in the 2022 midterm elections. To better understand how resource allocation is determined, I conducted a qualitative interview with a Philadelphia election official to identify how unequal allocation could occur. My findings suggest that community wealth is not a significant driver of voter wait times, but that racial gaps in wait times persist at the individual and local level. My findings also show that a racial voter wait gap exists in a number of states, and that differing laws or other factors at the state level either cause or contribute to the gap. Ultimately, this means that other factors must cause the racial voter wait time gap, including institutions and how resource allocation is determined