Amilcar Cabral, Colonial Soil and the Politics of Insubmission

This article discusses the concept of “insubmission.” This concept is the cornerstone of critical theory of Amílcar Cabral, one of the most important anticolonial thinkers of the twentieth century. Introduced in his early agronomic writings, it refers to the human species’ refusal to submit to the nature of which we are always a part. The context is the anticolonial critique of traditional European humanism. Insubmission is Cabral’s response to the dehumanising effects of colonialism and the environmental impact of anthropocentric extractivism that accompanies it. As a linchpin in Cabral’s theoretical framework, insubmission serves to structure and impart meaning to other concepts. Notably, it provides fresh insights into the multifaceted concept of “resistance.” Cabral underscores the imperative of combating dehumanisation through physical fortitude (physical and armed resistance), intellectual resilience (cultural resistance), and institutional strength (political resistance). Additionally, it emphasises the necessity of averting environmental catastrophes through a socio-economic development model (economic resistance) underpinned by a resolute ethical commitment to responsible soil conservation practices.“Race Trouble. Decolonizing race and racial inequality in postcolonial Portugal” (2022.04225.PTDC) exploratory research project, funded by the Foundation for Science and Technology, Portuguese Ministry for Science, Technology and Higher Education

Vulcanization of polypropylene

Publication status: PublishedAbstractDynamic covalent crosslinking of commodity thermoplastics is a desirable target in material development, as it promises to combine the enhanced mechanical properties and thermal/solvent stability of thermosets with reprocessability and plastic flow under certain conditions activating the bond exchange. Many attempts of this development suffer from the same two problems: enhanced cost due to complex and often toxic chemicals, and the effective melt‐flow index being too low for practical use. Here we return to the origins of polymer networks, and mimic the vulcanization of natural rubber in the commodity polypropylene using elemental sulfur initiated by peroxide. Forming sulfur bridges allows easy catalyst‐free reprocessability based on the disulfide bond exchange. We study a broad range of compositions and reaction conditions, finding optimal balance between the crosslinking and chain scission in the melt compounder, and demonstrating much enhanced characteristics of the resulting materials. We specifically discuss and evaluate the balance between the rubber‐elastic network response at high temperatures and the plastic flow enabled by disulfide exchange, responsible for the reprocessing of our vitrimers.</jats:p

Critique refigured: art, activism, and politics in post‐recession Dublin

Publication status: PublishedAbstractThis article argues that the anthropology of critique has been hampered by an implicit framing of critique as the content of knowledge rather than an orientation to knowledge about the world. It does so building on an ethnographic account of a group of critical citizens in post‐recession Dublin, Ireland. It stages a comparison between two different forms of critique of importance to them: art and activism. Contrary to the assumption that activism and detachment, and moral advocacy and empiricism, are at odds, this ethnographic comparison reveals that here the ultimate critical skill is thought to be the ability to take up different critical attitudes. Moreover, it isn't a lack of detachment but the creation of a ‘critical community’ that makes critique political. Drawing from this ethnographic instance of what counts as critique, this article thus makes a case for an anthropology of critique as itself a critical practice – one that is becoming increasingly urgent as critique as we know it has come to exhibit a hegemony of form in the social sciences and public cultures of debate.</jats:p

21st century progress in computing

In the search for explanations for slower productivity growth since the mid-2000s in many countries, one possibility is a slower pace of progress in digital technologies. In this paper we show that the cost of computation has continued to decline rapidly, taking into account innovation in chip types and cloud computing. This is a continuation of its long-run trend; the decline has slowed since 2010, but not earlier. As firms use computational power along with other inputs including relevant human and organisational capital, to the extent that the productivity slowdown is linked to technology use the explanation is likely to lie in these other elements of the input bundle

A Syntax for Connection Proofs

Providing a proof certificate is one of the most important features of (fully automated) theorem proving systems. For theorem provers based on, e.g, resolution or superposition calculi, a syntax for writing solutions is well documented and used. Even though attempts have been made to specify a syntax for connection calculi, there is currently no such syntax in common use. This paper provides an overview of the proof syntax used by existing connection provers and proposes an improved syntax for connection proofs. Due to the general approach, the syntax can be extended to also represent connection proofs in some non-classical logics

Super-Efficient and Highly Biocompatible Nanosystems for 2-Photon Photodynamic Therapy of Adrenergic Disorders

Acknowledgements: This manuscript is dedicated to Dr Raoul Kopelman (October 21, 1933–July 20, 2023). RK acknowledges the National Cancer Institute for funding support (R01CA186769, R01CA250499). The authors thank the BRCF Microscopy Core at The University of Michigan for providing the equipment and guidance for both the 2p-PDT and TEM work. The authors also would like to thank Prof. Oren A. Scherman, Prof. Silvia Vignolini, and Dr Jade A. McCune at the University of Cambridge for providing the equipment and guidance necessary to run the aqueous gel permeation chromatography (GPC) found in the ESI† of this text.Two highly biocompatible nanosystems have been designed, synthesized, characterized, and demonstrated in vitro for enhanced 2-photon photodynamic therapy (2p-PDT) of adrenergic disorders. These systems consist of a compact, star-shaped, 8-arm...</jats:p

A time- and single-cell-resolved model of murine bone marrow hematopoiesis.

The paradigmatic hematopoietic tree model is increasingly recognized to be limited, as it is based on heterogeneous populations largely defined by non-homeostatic assays testing cell fate potentials. Here, we combine persistent labeling with time-series single-cell RNA sequencing to build a real-time, quantitative model of in vivo tissue dynamics for murine bone marrow hematopoiesis. We couple cascading single-cell expression patterns with dynamic changes in differentiation and growth speeds. The resulting explicit linkage between molecular states and cellular behavior reveals widely varying self-renewal and differentiation properties across distinct lineages. Transplanted stem cells show strong acceleration of differentiation at specific stages of erythroid and neutrophil production, illustrating how the model can quantify the impact of perturbations. Our reconstruction of dynamic behavior from snapshot measurements is akin to how a kinetoscope allows sequential images to merge into a movie. We posit that this approach is generally applicable to understanding tissue-scale dynamics at high resolution

Management of mild degenerative cervical myelopathy and asymptomatic spinal cord compression: an international survey.

STUDY DESIGN: Cross-sectional survey. OBJECTIVE: Currently there is limited evidence and guidance on the management of mild degenerative cervical myelopathy (DCM) and asymptomatic spinal cord compression (ASCC). Anecdotal evidence suggest variance in clinical practice. The objectives of this study were to assess current practice and to quantify the variability in clinical practice. METHODS: Spinal surgeons and some additional health professionals completed a web-based survey distributed by email to members of AO Spine and the Cervical Spine Research Society (CSRS) North American Society. Questions captured experience with DCM, frequency of DCM patient encounters, and standard of practice in the assessment of DCM. Further questions assessed the definition and management of mild DCM, and the management of ASCC. RESULTS: A total of 699 respondents, mostly surgeons, completed the survey. Every world region was represented in the responses. Half (50.1%, n = 359) had greater than 10 years of professional experience with DCM. For mild DCM, standardised follow-up for non-operative patients was reported by 488 respondents (69.5%). Follow-up included a heterogeneous mix of investigations, most often at 6-month intervals (32.9%, n = 158). There was some inconsistency regarding which clinical features would cause a surgeon to counsel a patient towards surgery. Practice for ASCC aligned closely with mild DCM. Finally, there were some contradictory definitions of mild DCM provided in the form of free text. CONCLUSIONS: Professionals typically offer outpatient follow up for patients with mild DCM and/or asymptomatic ASCC. However, what this constitutes varies widely. Further research is needed to define best practice and support patient care

A Fluorinated BODIPY-Based Zirconium Metal-Organic Framework for In Vivo Enhanced Photodynamic Therapy.

Publication status: PublishedPhotodynamic therapy (PDT), an emergent noninvasive cancer treatment, is largely dependent on the presence of efficient photosensitizers (PSs) and a sufficient oxygen supply. However, the therapeutic efficacy of PSs is greatly compromised by poor solubility, aggregation tendency, and oxygen depletion within solid tumors during PDT in hypoxic microenvironments. Despite the potential of PS-based metal-organic frameworks (MOFs), addressing hypoxia remains challenging. Boron dipyrromethene (BODIPY) chromophores, with excellent photostability, have exhibited great potential in PDT and bioimaging. However, their practical application suffers from limited chemical stability under harsh MOF synthesis conditions. Herein, we report the synthesis of the first example of a Zr-based MOF, namely, 69-L2, exclusively constructed from the BODIPY-derived ligands via a single-crystal to single-crystal post-synthetic exchange, where a direct solvothermal method is not applicable. To increase the PDT performance in hypoxia, we modify 69-L2 with fluorinated phosphate-functionalized methoxy poly(ethylene glycol). The resulting 69-L2@F is an oxygen carrier, enabling tumor oxygenation and simultaneously acting as a PS for reactive oxygen species (ROS) generation under LED irradiation. We demonstrate that 69-L2@F has an enhanced PDT effect in triple-negative breast cancer MDA-MB-231 cells under both normoxia and hypoxia. Following positive results, we evaluated the in vivo activity of 69-L2@F with a hydrogel, enabling local therapy in a triple-negative breast cancer mice model and achieving exceptional antitumor efficacy in only 2 days. We envision BODIPY-based Zr-MOFs to provide a solution for hypoxia relief and maximize efficacy during in vivo PDT, offering new insights into the design of promising MOF-based PSs for hypoxic tumors

Myths and common misbeliefs about cervical cancer causation among Palestinian women: a national cross-sectional study.

Acknowledgements: The authors would like to thank all participants who took part into the study.BACKGROUND: Cervical cancer (CC) myths and beliefs can negatively impact women's preventive behaviors, including vaccination against human papillomavirus and having regular screening tests. This study aimed to examine awareness of Palestinian women about myths related to CC causation and investigated factors associated with good awareness. METHODS: A national cross-sectional study was conducted to recruit adult Palestinian women from hospitals, primary healthcare facilities, and public areas in 11 Palestinian governorates. A translated-into-Arabic version of the Cancer Awareness Measure-Mythical Causes Scale was used to collect data. Awareness level was determined based on the number of CC myths around CC causation recognized to be incorrect: poor (0-4), fair (5-9), and good (10-13). RESULTS: A total of 7058 questionnaires were included. Myths unrelated to food were more commonly recognized as incorrect compared to those related to food. The most recognized food-unrelated myth was 'having a physical trauma' (n = 3714, 52.6%), whereas the least recognized was 'using mobile phones' (n = 2238, 31.7%). The most recognized food-related myth was 'drinking from plastic bottles' (n = 2708, 38.4%), whereas the least recognized was 'eating food containing additives' (n = 1118, 15.8%). Only 575 participants (8.1%) displayed good awareness and promptly recognized at least 10 out of 13 myths around CC causation as incorrect. Factors associated with lower likelihood of displaying good awareness of myths around CC causation included living in the West Bank and Jerusalem, being married, widowed or divorced, knowing someone with cancer, and visiting hospitals or primary healthcare centers. CONCLUSIONS: A very small proportion of Palestinian women recognized 10 or more myths around CC causes as incorrect. Initiatives addressing CC myths are needed in the Palestinian community