DES update

Caption title.Also available via the World Wide Web as an Acrobat .pdf file (2.54, 119 p.).Includes bibliographical references

Voluntary HIV counseling and testing: facts, issues, and answers

HIV/NAIEP/10-90/11

International health data reference guide

NCHS.Title from caption.Vols. for 1983-1987 issued as DHHS publication.Vol. for 1985 published by the Office of International Statistics, National Center for Health Statistics; 1987 by the International Statistics Staff, Office of Planning and Extramural Programs, National Center for Health Statistics

J Environ Health

20142015-11-01T00:00:00ZCC999999/Intramural CDC HHS/United States25603622PMC4561993891

Emerg Infect Dis

Rosa Bonheur (1822\u20131899) Plowing in Nivernais (1850) Oil on canvas (133.4 cm 7 259.1 cm) SN433 Collection of the John and Mable Ringling Museum of Art, the State Art Museum of Florida, a Division of Florida State University

Emerg Infect Dis

We identified discrete importation events of the mcr-1 gene on incompatibility group IncI2 plasmids in Escherichia coli isolated from patients in New South Wales, Australia, in 2011 and 2013. mcr-1 is present in a small minority of colistin-resistant Enterobacteriaceae and appears not to be established locally

Emerg Infect Dis

In 1976, 2 recruits at Fort Dix, New Jersey, had an influenza like illness. Isolates of virus taken from them included A/New Jersey/76 (Hsw1n1), a strain similar to the virus believed at the time to be the cause of the 1918 pandemic, commonly known as swine flu. Serologic studies at Fort Dix suggested that >200 soldiers had been infected and that person-to-person transmission had occurred. We review the process by which these events led to the public health decision to mass-vaccinate the American public against the virus and the subsequent events that led to the program's cancellation. Observations of policy and implementation success and failures are presented that could help guide decisions regarding avian influenza

Transfusion

BACKGROUNDBabesiosis is an emerging tick-borne infection in humans. The increasing numbers of reported cases of transfusion-associated babesiosis (TAB), primarily caused by Babesia microti, represents a concern for the safety of the U.S. blood supply.STUDY DESIGN AND METHODSThis study investigated kinetics of parasitemia, innate immune responses and dynamics of antibody responses during B. microti infection in rhesus macaques using blood smears, quantitative PCR (qPCR), flow cytometry, and indirect fluorescent antibody testing. A total of 6 monkeys were transfused with either hamster or monkey-passaged B. microti infected erythrocytes (2 and 4 monkeys, respectively) simulating TAB.RESULTSThe prepatent period in monkeys inoculated with hamster-passaged B. microti was 35 days compared with 4 days in monkeys transfused with monkey-passaged B. microti; the latter monkeys also had markedly higher parasitemia levels. The duration of the window period from the first detected parasitemia by qPCR analysis to the first detected antibody response ranged from 10\u201317 days. Antibody responses fluctuated during the course of the infection. Innate responses assessed by the frequencies of monocytes and activated B cells correlated with the kinetics and magnitude of parasitemia. On day 14, additional activation peaks were noted for CD14+CD16+ and CD14 12CD16+ monocytes and for CD11c+ myeloid dendritic cells, but only in animals transfused with monkey-passaged B. microti. Parasitemia persisted in these immunocompetent animals, similar to human infection.CONCLUSIONThe results suggest that transfusion-associated transmission of B. microti leads to rapid onset of parasitemia (day 4) in rhesus macaques, detectable antibody response 14 days later and persistent parasitemia.CC999999/Intramural CDC HHS/United StatesP30 AI050409/AI/NIAID NIH HHS/United StatesP51 OD011132/OD/NIH HHS/United StatesR24 OD010947/OD/NIH HHS/United State