University of Tennessee at Chattanooga

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    Understanding Taf13 (TATA box-binding protein-associated factor 13) upregulation in eukaryotic cells

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    TATA-binding protein (TBP) and TBP-associated factors (Tafs) comprise RNA Polymerase II (RNA Pol II) pre-initiation complex. This universal component carefully controls the transcriptional initiation process. One of the Tafs, Taf13, also plays an important role in the regulation of RNA Pol II transcription initiation which is evolutionarily conserved from yeast to humans. It is found that Taf13 is overexpressed in cancer cells, although the exact mechanism that is responsible for this overexpression is unclear. Our hypothesis suggests that targeted degradation by the 26S proteasome via ubiquitylation [Ubiquitin-Proteasome System (UPS)] may be the mechanism that regulates the stability of Taf13. To test this possibility, we evaluated the role of UPS on the stability of Taf13 in yeast (Saccharomyces cerevisiae). Importantly for the first time, we found that Taf13 undergoes polyubiquitylation but it is not regulated by the 26S proteasome. These findings suggest further oncologic research topics for the development of therapeutic interventions for future patients of cancer

    Nonduality and identity: an exploration of form, genre, and perspective

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    This thesis utilizes hybrid forms of poetry and prose to examine questions of nonduality, perspective, and identity, simultaneously testing the boundaries of genre and form as a whole. The opening craft essay offers a more specific analysis of form and genre, particularly those of poetry / prose and fiction / nonfiction, while the creative writing demonstrates how such differentia are relevant to the art of creative writing

    Here (toma): translations between me and my mother

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    The lyric mode can be thought of as the engine of a piece, what drives its thinking and structure forward. Memoir writing most often refers to writing based on an author\u27s own memories. For these two reasons, I\u27ve labeled my Honors thesis a lyric memoir. The memoir consists of poems, translated into Spanish by my mother, dual essays in which I share the page with another writer, and after essays which consider a wide variety of topics on identity, death, religion, and language. Critically, what makes the memoir lyric is its lack of direct narrative, instead relying on the layering, associative effect of the lyric to move forward. In my craft paper, I argue the armor of the lyric mode lends itself particularly well to writing memoir, writing of family, of absent things, and things too multiplicitous to render linearly on the page

    Sylvia Plath’s fig tree: discourse formation and the production and consumption of women’s identity

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    Investigating the formation of women\u27s identities within Sylvia Plath\u27s work, this paper seeks to understand the position of women within society during Plath\u27s lifetime and in the wake of her death. Comparing genres of both public, private, and semi-public writing, I hinge my argument on Plath\u27s famous fig tree passage to understand three distinct feminine identities and the inherent consumption and production that accompanies women\u27s identity formation

    “Bad taste, bad hygiene, and bad morals:” dress reform movements and women’s fight for greater independence during the late 1800s.

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    The Victorian Age is debated as a time of brilliant growth, beauty, and prosperity for people living in England. While this era is described as a glory age for England, it was also an age of great inequality. There were significant advancements in learning and new societal freedom, like the widespread availability of education and abundance of jobs. However, freedom was not experienced equally by everyone in the public. One of the main things women sought to change was freedom in their wardrobe. It was nearly impossible to progress in society under the rigid restrictions women’s clothes put on them. Women’s bodies were supposed to be hidden and modest, representing the future that lay ahead. As an integral part of their identity, women’s wardrobes became a source of increased scrutiny. Fashion was one of the first notable factors that changed the way women participated in overall outside life. In this research project, I will cover two dress reform movements that relate to the change in women’s fashion and why fashion was an important catalyst to gaining women’s independence. These two movements are the Aesthetic Movement, which emerged in the latter years of the Victorian Era, and the Rational Dress Movement, which picked up the Aesthetic Movement’s mission in achieving change in women’s wardrobes. Both movements follow the struggles that women had to face to achieve just a fraction of the amount of freedom that others had through their fashion. While other movements like the suffrage and temperance movement coincided with these fashion movements, the change in clothes was an undervalued factor that helped women gain further independence. The change in women’s clothes and fashion movements was a major catalyst in the fight for bodily autonomy and the breakdown of the public and private spheres. Without the fashion movements in the 1800s and women speaking up when they did, other freedoms for women might not have been realized. The evolution of women’s fashion changed the course for women in the new century

    Sensitivity analysis and simulations of surface heating for hypersonic cavity flows

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    Hypersonic flow over cavities results in instabilities and discontinuities that affect the surface properties, and potentially results in surface damage. Simulations were performed using semi-structured 2D meshes in FUN3D with the Spalart-Allmaras and Menter Shear Stress Transport turbulence models at a freestream Mach number of 10. The geometry includes a flat plate and four cavities with length-to-height (L/H) ratios of 0.17, 5, 15, and 30. The surface heating is found to have a strong sensitivity to freestream Reynolds numbers and some sensitivity to a change in the wall temperature. The cavity flow results are compared to Nestler et al.’s experimental data and Holifield’s CFD results. The cavities with an L/H greater than 1 presented a good match to the experimental data for both heating and pressure. The flow did not fully develop at the bottom of the L/H 0.17 gap, resulting in less accurate results close to the cavity floor

    BookTok: the cultural phenomenon introducing a stagnated industry to a new generation

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    BookTok, a creator-driven subset of TikTok that promotes and discusses books, gained popularity in 2020. Its emergence has significantly altered the book industry, allowing once-unknown authors to transform into bestselling novelists with the click of a button. Modern romance, fantasy, and young adult novels are typically favored on BookTok. These novels are vastly different from the books in the traditional literary canon, challenging conventional ideals regarding what types of literature could be considered canonical. Additionally, BookTok is primarily driven by younger users, allowing many teenagers and young adults to rediscover the joy found through reading and writing. This research project focuses on a question regarding BookTok’s relationship to traditional literature: “BookTok: Is the social media phenomenon opening the notably gatekept literary canon to a new generation of authors and connoisseurs, or is it creating a new canon entirely?” Through examining evidence from an IRB-approved study distributed to more than 300 avid readers, perusing scholarly research, and conducting an in-depth literature examination of canonical and modern-day novels, we determined the extent to which BookTok has changed the literary industry. This project discovered that (1) reading habits are shifting among teenagers and young adults, (2) BookTok is offering new book marketing tactics, (3) canonical novels are different from the novels popular on BookTok, and (4) BookTok is a viable (but unpredictable) marketing method

    Disney\u27s postfeminist follies: Disney’s postfeminist portrayal of women in the age of fourth wave of feminism

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    In 2022, Disney CEO Bob Chepak spoke out against the Don\u27t Say Gay bill signed by Florida Governor Ron DeSantis. DeSantis’ supporters derisively labeled Disney as “woke. However, the company does not warrant the label. Though Fourth Wave feminism has broadened Disney’s idea of a woman, the entertainment company largely operates with a postfeminist lens that prevents its heroines from being feminist representations of women. Audiences see this in Frozen, (2013), Moana (2016), Encanto (2021), and Turning Red (2022). Disney’s postfeminist rhetoric allows it to portray supposedly progressive women without challenging societal notions of misogyny. Thus, Disney’s criticisms for “wokeness” are largely unfounded claims as it remains largely conservative in its portrayal of masculinity and femininity

    A study of the relationship between interoceptive sensibility and distress tolerance in community and college samples

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    Interoceptive sensibility (IS) involves the detection, integration, and interpretation of internal bodily signals, primarily from cardiovascular, pulmonary, or gastrointestinal systems. Dysfunction in interoceptive processing has been increasingly recognized as a clinically relevant factor in numerous neurological, psychiatric, and behavioral disorders. This thesis aimed to elucidate the relationship between interoceptive sensibility and distress tolerance, hypothesizing that individuals with heightened interoceptive sensibility may exhibit poorer distress tolerance, potentially influencing emotional regulation and maladaptive coping mechanisms. To explore these relationships, two studies have been conducted utilizing self-report measures of interoceptive sensibility and distress tolerance in community and college samples. In a study of college students, a significant positive correlation between interoceptive sensibility and poorer distress tolerance. In a study recruiting participants from a south-eastern United States metropolitan area, a non-significant positive relationship between interoceptive sensibility and poorer distress tolerance. Implications, limitations, and future directions are discussed

    Intersectionality and employment barriers: analyzing age and gender bias in job advertisements

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    Different forms of discrimination occur within phases of the employment process (attraction, selection, retention), with an estimated 20-40% of employers influenced by bias in their hiring decisions. Sexism and ageism are among the most prevalent forms; however, detecting hiring discrimination is complex and often unreported. The current study focused on the attraction phase to examine how age and gender intersect to create employment barriers and opportunities. A sample of 800 job ads were collected from white-collar, blue-collar, female-and-male-dominated occupations across the U.S. Using a mixed methods approach, data were analyzed through an exploratory, content analysis to identify previous and nuanced gendered and age biased language to develop a repository for LIWC to conduct a series of 2x2 factorial ANOVAs. A significant interaction was found between job industry and gender dominance in the gendered age language bias to indicate a young man candidate. Limitations, future directions, and implications are discussed

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