防災都市づくり計画の利点と課題に関する研究 －策定地域の取組みを踏まえて－

Japan is a country prone to earthquakes, and in addition, due to climate change, damage from torrential rains is increasing. Local governments are promoting the development of disaster prevention and mitigation cities that assume the occurrence of various disasters, and the basic plans for this are Rocal Disaster Management Plans and Municipal Urban Master Plans. However, it cannot be said that these two plans are fully coordinated. Therefore, in the wake of the Great Hanshin-Awaji Earthquake, the ``Disaster Prevention Urban Plan'' was established as a way to connect both sides. However, Disaster Prevention Urban plans are not based on laws and regulations, and therefore only a few local governments have developed them. The purpose of this study is to clarify the benefits and challenges associated with the formulation of Disaster Prevention Urban plans by investigating the process behind the formulation by local governments that are formulating Disaster Prevention Urban plans, specific measures, and the situation of residents after formulation. Based on the results of this interview, it is necessary to fully assess disaster risk at the beginning of planning, determine target disasters, and reflect this in measures. It is also assumed that more coordinated plans can be created by involving both the Local Disaster Management Plan and Municipal Master Plan planners. It is inferred that not only the planning but also holding briefing sessions and support for citizens after the planning and after disaster prevention projects will lead to improved disaster prevention awareness.長崎大学大学院工学研究科研究報告, 55(104), pp.86-93; 2025departmental bulletin pape

企業主導型保育園との連携―文教おもやい保育園における「異文化交流の時間」活動報告―

長崎大学ダイバーシティ推進センター研究紀要, 3, pp.31-37; 2025departmental bulletin pape

Living Donor Liver Transplantation with Small Left Lobe Grafts: Prospective Validation of Utility of Splenectomy in Selected Recipients

BACKGROUND: We previously reported that the Model for End-stage Liver Disease (MELD) score and donor age are risk factors for small-for-size syndrome in adult living donor liver transplantation (LDLT) involving small grafts. Since April 2021, we have performed splenectomy as a portal inflow modulation in LDLT using small grafts according to the presence of risk factors. In this study, we evaluated the validity of our splenectomy strategies for optimizing graft outcomes. MATERIAL AND METHODS: We retrospectively reviewed patients who underwent primary LDLT using left lobe grafts with the middle hepatic vein from January 2005 to January 2024 at our institution. We also compared the graft outcomes between recipients who underwent LDLT beginning in April 2021 (current policy group) and those who underwent LDLT in the era when splenectomy as portal modulation was not indicated (previous policy group). RESULTS: In total, 173 consecutive LDLTs (current policy group: n=15) involving left lobe grafts were analyzed. Splenectomy was performed in 9 of 15 (60.0%) patients in the current policy group. All 15 patients in the current policy group remained alive for a median follow-up of 20.5 months. The rate of early allograft dysfunction was significantly lower, and the rate of small-for-size syndrome tended to be lower in the current policy group than in the previous policy group (13.3% vs 39.2%, P=0.047 and 20.0% vs 36.1%, P=0.211, respectively). CONCLUSIONS: LDLT with splenectomy for high-risk patients may expand the availability of small left lobe grafts and optimize graft outcomes.Annals of transplantation, 30, art. no. e946374; 2025journal articl

Successful granulocyte-macrophage colony-stimulating factor inhalation therapy for recurrent autoimmune pulmonary alveolar proteinosis after lung transplantation: A case report

Sargramostim, a recombinant human granulocyte-macrophage colony-stimulating factor (GM-CSF) inhalation therapy, was recently approved for pharmaceutical use in Japan and shows promise as a treatment for autoimmune pulmonary alveolar proteinosis (APAP). For APAP patients with severe respiratory failure due to advanced lung fibrosis, lung transplantation is also a treatment option; however, APAP may recur after the procedure. Here, we report a case of successful sargramostim inhalation therapy for post-transplant APAP relapse in a patient who underwent living lung transplantation owing to severe fibrosis. Inhaled GM-CSF may be a useful treatment option for APAP recurrence in patients who have undergone lung transplantation.Respiratory Investigation, 63(1), pp.180-182; 2025journal articl

Development and functional evaluation of a psoralen-conjugated nucleoside mimic for triplex-forming oligonucleotides

Psoralen-conjugated triplex-forming oligonucleotides (Ps-TFOs) have been employed for the photodynamic regulation of gene expression by the photo-cross-linking of psoralen with the target DNA. However, stable triplex formation requires a consecutive purine base sequence in one strand of the target DNA duplexes. The pyrimidine-base interruption in the consecutive purine base sequence drastically decreases the thermodynamic stability of the corresponding triplex, which hampers the TFO application. Here, we propose a design of the Ps-TFO for stable triplex formation with target DNA sequences containing pyrimidine-base interruptions under physiological conditions. This Ps-TFO, named 1’(one)-psoralen-conjugated triplex-forming oligonucleotide (OPTO), incorporates a synthesized nucleoside mimic 1’-psoralen-conjugated deoxyribose to increase the thermodynamic stability of the corresponding triplex by the intercalation of psoralen. The triplex-forming abilities of the OPTO were successfully demonstrated in combination with LNA and 5-methylcytosine, indicating that the use of OPTO will expand the range of the target sequences of TFO for photodynamic gene regulation.Communications Chemistry, 8(1), art. no. 18; 2025journal articl

Ecological overview of hard ticks (Ixodida: Ixodidae) in Nagasaki prefecture of western Japan during winter 2021–2022

In Japan, Japanese spotted fever, Lyme disease and severe fever with thrombocytopenia syndrome caused by Ixodidae species are endemic. To prevent and control the diseases, fundamental understandings in tick ecology are crucial. Hence, this study aimed to analyse tick species richness and abundance across Nagasaki prefecture including its remote islands from a wide range of environments. A total of 74 sampling points screening during winter 2021–2022, using dragging method resulted in 14,883 tick samples (279 adults, 7148 nymphs and 7456 larvae) in 11 species belonging to four genera. Haemaphysalis flava dominated adult populations, while H. formosensis was predominant among nymphs. Both species are possible vectors of Japanese spotted fever and severe fever with thrombocytopenia syndrome. The ecological analysis revealed more complex species distribution in the remote islands compering to the main island in both adults and nymphs. In addition, the ground temperature was a significant regulatory factor for both adults and nymphs. The research provides valuable insights on tick distributions, ecological groupings and environmental preferences in Nagasaki. These findings contribute to the fundamental understanding of tick ecology and could contribute to design strategies for tick population control and tick-borne disease prevention in Nagasaki or possibility to nearby areas.Scientific Reports, 15(1), art. no. 4114; 2025journal articl

Vol.13 No.2

RECNA Newsletter, 13(2), pp.1-6; 2025othe

Investigation on stress distribution and prestress loss model of prestressed anchor cables considering corrosion-induced debonding

Corrosion can significantly impact the safety and stability of the entire structure by reducing the service life and load-bearing capacity of anchors. This study provides an in-depth examination of the effects of corrosion on prestressed anchor cables, covering the effects on the anchor cables themselves and the bond interface. The force characteristics and load transfer mechanisms within the anchorage structure were explored through a detailed analysis of the three key components: the anchor cable, the grout, and the surrounding rock. The distribution functions of axial force and interfacial shear stress considering the debonding of the anchor-grout interface were derived, and the prestressed corrosion damage model was further developed. Taking the anchoring project on the slopes in Nagasaki as an example, the stress distribution of anchor cables under different surrounding rock conditions was analyzed in depth. The results showed that the relative deformation of the grout and the surrounding rock decreases when the elasticity modulus of the surrounding rock increases, resulting in a reduced axial force in anchor cables and an increased interface shear stress. Thresholds exist for the effect of the total anchor length and radius on prestressing stability. When designing anchor structures in corrosive environments, there is no need to choose excessive anchor length or anchor radius to achieve better cost-effectiveness. In practical underground engineering, the force in anchor cables is transferred to the surrounding rock through the anchoring section, where the length of the anchorage section has a more direct impact on prestress transfer and stability.Rock Mechanics Bulletin, 4(2), art. no. 100189; 2025journal articl

イスラエル基本法上の財産権とヨルダン川西岸地区における住居破壊について―2023年3月６日イスラエル最高裁判所判例を手がかりとして―

As Israel’s conflicts with neighboring countries and Islamist organizations intensify, the number of Palestinians facing house demolitions in the West Bank has significantly increased. While there are some Israeli Supreme Court cases that held that property rights guaranteed under the Basic Law of Israel were recognized for Palestinians in the West Bank, should the house demolitions of Palestinians in the West Bank constitute a violation of property rights under the Basic Law of Israel? This paper discusses how the legal basis for the house demolitions of Palestinians is administered by the Courts in Israel, based on an analysis of a recent Israeli Supreme Court case involving the house demolition of Palestinians in the West Bank. This paper finds that, in accordance with the criteria for human rights restrictions in Article 8 “Violation of rights” in the Basic Law: Human Dignity and Liberty, the house demolitions of Palestinians in the West Bank cannot be illegal because they have, based on the Defense (Emergency) regulations, the proper purpose of deterring the occurrence of terrorist acts, the violation of rights is kept to a minimum, and are consistent with the values of the State of Israel.多文化社会研究, 11, pp.97-115; 2025departmental bulletin pape

特集「地域とネットワークから華僑華人をとらえなおす」

多文化社会研究, 11, pp.117-118; 2025departmental bulletin pape