Sentido — Vida — Cosmos: un diálogo entre Martin Heidegger y Hans Jonas.

La pregunta por la apertura de sentido y la generación de significados es uno de los núcleos temáticos fundamentales de la fenomenología desde sus inicios con Edmund Husserl. El problema conductor del pensar heideggeriano es efectivamente la pregunta por el sentido del ser en general. Sin embargo, esta se mantiene atada a la apertura significativa del ser humano, en cuanto el concepto de mundo, como Eugen Fink destaca, tiene un carácter exclusivamente existencial. En el marco de la ontología de lo viviente de Hans Jonas se produce no solo una ampliación del concepto de mundo, de modo tal que este adquiere un carácter cosmológico, sino también de la apertura de sentido, en tanto a cada forma de lo viviente le es inherente una significatividad determinada en correspondencia con el principio de la libertad orgánica. En el seminario realizaremos una confrontación entre la fenomenología heideggeriana del mundo y la ontología de lo viviente de Hans Jonas de cara al concepto del sentido cosmológico

A putative novel type of tight adherence (tad) like gene cluster of Pseudomonas Chlororaphis PCL1606 exhibits a crucial role in avocado roots colonization, fostering its biological control activity

Aims Pseudomonas chlororaphis PCL1606 (PcPCL1606), displays strong antagonistic and biological control abilities against several soil-borne fungal pathogens mainly due to the production of the antifungal molecule 2-hexyl, 5-propyl resorcinol (HPR). HPR governs other beneficial phenotypes, suggesting its additional regulatory activity. Published transcriptomic data identifying HPR-regulated genes involved in the interaction of PcPCL1606 with the avocado rhizosphere were used as a target database to identify putative genes involved in avocado roots colonization. Methods The induction of several consecutive genes that showed homology with genes encoding a putative type IV Flp/Tad (tight adherence) pilus but with a few differences from the Tad type A and B was observed. To study the role of this tad-like gene cluster in the biology of PcPCL1606, a chromosomal deletion mutant was constructed. The molecular characterization of the tad-like gene cluster and different in vitro and in vivo phenotypes related to colonization were addressed in the mutant strain respect to PcPCL1606. Results The tad-like gene cluster was composed of five independent transcriptional units. Furthermore, the tad-like deletion mutant was impaired in early attachment, early biofilm formation, bacterial autoggregation and in root competitiveness in avocado plants and biocontrol activity against R. necatrix. Conclusions These results expand our understanding about the role of HPR as a putative signalling molecule. This study revealed the importance of a putative novel type of a Tad system of PcPCL1606 in the avocado roots colonization, confirming that initial attachment to roots is a fundamental mechanism for the PcPCL1606 rhizospheric performance.Funding for open access publishing: Universidad de Málaga/CBUA . This work was supported by PID2021-123713OB-I00 research project from the Ministerio de Ciencia, Innovacion y Universidades (Spain) and UMA18-FEDERJA-046 grant from Junta de Andalucía, both partially supported by the European Union (FEDER). Funding for open access charge: Universidad de Málaga / CBU

Benahavís lakes. Plan in which gated communities and Golf courses inside Benahavís municipality turn into water. Data: Benahavís town hall, Google Earth, elaborated by Jorge Minguet. Image base: Google Earth.

Plan in which gated communities and Golf courses inside Benahavís municipality turn into water. Data: Benahavís town hall, Google Earth, elaborated by Jorge Minguet. Image base: Google Earth. Plan en el que urbanizaciones cerradas y campos de Golf dentro del municipio de Benahavís se convierten en agua. Datos: Ayuntamiento de Benahavís, Google Earth, elaborado por Jorge Minguet. Base de imágenes: Google Earth. Datos proporcionados en 2019 por el Ayuntamiento de Benahavís y Google Earth, elaborados por el autor y trazados sobre base cartográfica de Google Earth. Data provided in 2019 by Benahavís Town Hall and Google Earth, elaborated by the author and traced over Google Earth cartographic base.Datos proporcionados en 2019 por el Ayuntamiento de Benahavís y Google Earth, elaborados por el autor y trazados sobre base cartográfica de Google Earth. Data provided in 2019 by Benahavís Town Hall and Google Earth, elaborated by the author and traced over Google Earth cartographic base

Named entity recognition for de-identifying Spanish electronic health records

Background and objectives: There is an increasing and renewed interest in Electronic Health Records (EHRs) as a substantial information source for clinical decision making. Consequently, automatic de-identification of EHRs is an indispensable task, since their dissociation from personal data is a necessary prerequisite for their dissemination. Nevertheless, the bulk of prior research in this domain has been conducted using English EHRs, given the limited availability of annotated corpora in other languages, including Spanish. Methods: In this study, the automatic de-identification of medical documents in Spanish was explored. A private corpus comprising 599 genuine clinical cases was annotated with eight different categories of protected health information. The prediction problem was approached as a named entity recognition task and two deep learning-based methodologies were developed. The first strategy was based on recurrent neural networks (RNN) and the second, an end-to-end approach, was based on Transformers. In addition, we have implemented a procedure to expand the amount of texts employed for model training. Results: Our findings demonstrate that Transformers surpass RNNs in the de-identification of clinical data in Spanish. Particularly noteworthy is the excellent performance of the XLM-RoBERTa large Transformer, achieving a rigorous strict-match micro-average of 0.946 for precision, 0.954 for recall, and an F1 score of 0.95 when applied to the amplified version of the corpus. Furthermore, a web-based application has been created to assist specialized clinicians in de-identifying EHRs through the aid of the implemented models. Conclusion: The study’s conclusions showcase the practical applicability of the state-of-the-art Transformers models for precise de-identification of clinical notes in real-world medical settings in Spanish, with the potential to improve performance if continual pre-training strategies are implemented.Funding for open access charge: Universidad de Málaga / CBUA. The authors acknowledge the support from the Ministerio de Ciencia e Innovación (MICINN) under project PID2020-116898RB-I00, from the Universidad de Málaga and Junta de Andalucía through grant UMA20-FEDERJA-045, from Pfizer S.L., the University of Malaga and the Fundación General UMA (UMA-FGUMA-Pfizer) through private funds

El sentido de la transferencia en el aprendizaje-servicio. ¿Quién transfiere a quién?

El proyecto de voluntariado, promovido por la Universidad de Málaga, se basa en el aprendizaje-servicio y se enfoca hacia “el fortalecimiento de las estructuras democráticas y de la sociedad civil y sus organizaciones”. Las actividades tienen como objetivo específico ofrecer un apoyo a la institución local, y así ofrecer una mejora en la resolución de las necesidades de los ciudadanos. La colaboración se extiende a otros ámbitos de intervención de la Alcaldía, apoyando los trabajos de concienciación ambiental, y hábitos saludables en la Casa Materna. El programa, financiado por la Agencia Andaluza de Cooperación Internacional al Desarrollo, permite el desplazamiento de los voluntarios durante dos meses, incluyendo una formación previa en cooperación al desarrollo. En el proyecto se hacen tangibles otros aspectos que promueven las prioridades sectoriales marcadas por AACID: ... El proyecto de aprendizaje-servicio en un contexto como Nicaragua, un país con un Índice de Desarrollo Humano (IDH) clasificado en el puesto 126 por Naciones Unidas, ha permitido una inmersión profunda en una cultura diferente, desafiando las perspectivas y capacidades de los participantes. Este entorno, significativamente diferente al lugar de salida, ha fomentado la autonomía y el compromiso, exigiendo la capacidad de adaptarse y trabajar en condiciones climáticas, con técnicas constructivas y dinámicas sociales distintas. La participación activa en los procesos de decisión y diseño ha fortalecido un enfoque colaborativo y respetuoso hacia los agentes locales, promoviendo una transferencia bidireccional de conocimientos y experiencias. Los voluntarios no solo han contribuido al fortalecimiento de las comunidades, sino que también han experimentado un crecimiento personal significativo, reflexionando sobre cuestiones éticas y redefiniendo su posición como personas y profesionales

Glutaminase-2 Expression Induces Metabolic Changes and Regulates Pyruvate Dehydrogenase Activity in Glioblastoma Cells

Glutaminase controls the first step in glutaminolysis, impacting bioenergetics, biosynthesis and oxidative stress. Two isoenzymes exist in humans, GLS and GLS2. GLS is considered prooncogenic and overexpressed in many tumours, while GLS2 may act as prooncogenic or as a tumour suppressor. Glioblastoma cells usually lack GLS2 while they express high GLS. We investigated how GLS2 expression modifies the metabolism of glioblastoma cells, looking for changes that may explain GLS2’s potential tumour suppressive role. We developed LN-229 glioblastoma cells stably expressing GLS2 and performed isotope tracing using U-13C-glutamine and metabolomic quantification to analyze metabolic changes. Treatment with GLS inhibitor CB-839 was also included to concomitantly inhibit endogenous GLS. GLS2 overexpression resulted in extensive metabolic changes, altering the TCA cycle by upregulating part of the cycle but blocking the synthesis of the 6-carbon intermediates from acetyl-CoA. Expression of GLS2 caused downregulation of PDH activity through phosphorylation of S293 of PDHA1. GLS2 also altered nucleotide levels and induced the accumulation of methylated metabolites and S-adenosyl methionine. These changes suggest that GLS2 may be a key regulator linking glutamine and glucose metabolism, also impacting nucleotides and epigenetics. Future research should ascertain the mechanisms involved and the generalizability of these findings in cancer or physiological conditions

Material audiovisual anexo a la monografía "Manual de Traducción Audiovisual francés-español".

Se trata de un material audiovisual complementario a la monografía titulada "Manual de Traducción Audiovisual (francés-español) que será publicada en febrero de 2025 por la autora en la editorial Comares.El monográfico al que acompaña dicho material audiovisual fue financiado por el Plan Propio Integral de Docencia del Vicerrectorado de Estudios de Grado de la Universidad de Málaga

Dynamical boundary value problem for a viscoelastic half-space with cut

The dynamical boundary value problem for viscoelastic half-space with cut in the form of a strip is considered. The problem is reduced to the singular integral equation of first kind. Using the method of orthogonal polynomials, the integral equation is reduced to an infinite system of linear algebraic equations. The quasi-completely regularity of the obtained system is proved and the reduction method for approximate solution is developed.Funding for open access publishing: Universidad de Málaga/CBU