The connection between the escape of ionizing radiation and galaxy properties at z ∼ 3 in the Keck Lyman continuum spectroscopic survey

The connection between the escape fraction of ionizing radiation (f_(esc)) and the properties of galaxies, such as stellar mass (⁠M_∗⁠), age, star-formation rate (SFR), and dust content, are key inputs for reionization models, but many of these relationships remain untested at high redshift. We present an analysis of a sample of 96 z ∼ 3 galaxies from the Keck Lyman Continuum Spectroscopic Survey (KLCS). These galaxies have both sensitive Keck/LRIS spectroscopic measurements of the Lyman continuum (LyC) region, and multiband photometry that places constraints on stellar population parameters. We construct composite spectra from subsamples binned as a function of galaxy property and quantify the ionizing-photon escape for each composite. We find a significant anti-correlation between f_(esc) and M_∗⁠, consistent with predictions from cosmological zoom-in simulations. We also find significant anti-correlation between f_(esc) and E(B−V), encoding the underlying physics of LyC escape in our sample. We also find no significant correlation between fesc and either stellar age or specific SFR (= SFR/M_∗⁠), challenging interpretations that synchronize recent star formation and favorable conditions for ionizing escape. The galaxy properties now shown to correlate with fesc in the KLCS are Lyα equivalent width, UV Luminosity, M_∗⁠, SFR, and E(B−V), but not age or sSFR. This comprehensive analysis of galaxy properties and LyC escape at high redshift will be used to guide future models and observations of the reionization epoch

TESS Hunt for Young and Maturing Exoplanets (THYME). IX. A 27 Myr Extended Population of Lower Centaurus Crux with a Transiting Two-planet System

We report the discovery and characterization of a nearby (∼85 pc), older (27 ± 3 Myr), distributed stellar population near Lower Centaurus Crux (LCC), initially identified by searching for stars comoving with a candidate transiting planet from TESS (HD 109833; TOI 1097). We determine the association membership using Gaia kinematics, color–magnitude information, and rotation periods of candidate members. We measure its age using isochrones, gyrochronology, and Li depletion. While the association is near known populations of LCC, we find that it is older than any previously found LCC subgroup (10–16 Myr), and distinct in both position and velocity. In addition to the candidate planets around HD 109833, the association contains four directly imaged planetary-mass companions around three stars, YSES-1, YSES-2, and HD 95086, all of which were previously assigned membership in the younger LCC. Using the Notch pipeline, we identify a second candidate transiting planet around HD 109833. We use a suite of ground-based follow-up observations to validate the two transit signals as planetary in nature. HD 109833 b and c join the small but growing population of <100 Myr transiting planets from TESS. HD 109833 has a rotation period and Li abundance indicative of a young age (≲100 Myr), but a position and velocity on the outskirts of the new population, lower Li levels than similar members, and a color–magnitude diagram position below model predictions for 27 Myr. So, we cannot reject the possibility that HD 109833 is a young field star coincidentally nearby the population

Quantitative measurement of the requirement of diverse protein degradation pathways in MHC class I peptide presentation

Peptides from degradation of intracellular proteins are continuously displayed by major histocompatibility complex (MHC) class I. To better understand origins of these peptides, we performed a comprehensive census of the class I peptide repertoire in the presence and absence of ubiquitin-proteasome system (UPS) activity upon developing optimized methodology to enrich for and quantify these peptides. Whereas most class I peptides are dependent on the UPS for their generation, a surprising 30%, enriched in peptides of mitochondrial origin, appears independent of the UPS. A further ~10% of peptides were found to be dependent on the proteasome but independent of ubiquitination for their generation. Notably, clinically achievable partial inhibition of the proteasome resulted in display of atypical peptides. Our results suggest that generation of MHC class I•peptide complexes is more complex than previously recognized, with UPS-dependent and UPS-independent components; paradoxically, alternative protein degradation pathways also generate class I peptides when canonical pathways are impaired

Daily SARS-CoV-2 Nasal Antigen Tests Miss Infected and Presumably Infectious People Due to Viral Load Differences among Specimen Types

In a recent household transmission study of SARS-CoV-2, we found extreme differences in SARS-CoV-2 viral loads among paired saliva, anterior nares swab (ANS), and oropharyngeal swab specimens collected from the same time point. We hypothesized these differences may hinder low-analytical-sensitivity assays (including antigen rapid diagnostic tests [Ag-RDTs]) by using a single specimen type (e.g., ANS) from reliably detecting infected and infectious individuals. We evaluated daily at-home ANS Ag-RDTs (Quidel QuickVue) in a cross-sectional analysis of 228 individuals and a longitudinal analysis (throughout infection) of 17 individuals enrolled early in the course of infection. Ag-RDT results were compared to reverse transcription-quantitative PCR (RT-qPCR) results and high, presumably infectious viral loads (in each, or any, specimen type). The ANS Ag-RDT correctly detected only 44% of time points from infected individuals on cross-sectional analysis, and this population had an inferred limit of detection of 7.6 × 10⁶ copies/mL. From the longitudinal cohort, daily Ag-RDT clinical sensitivity was very low (<3%) during the early, preinfectious period of the infection. Further, the Ag-RDT detected ≤63% of presumably infectious time points. The poor observed clinical sensitivity of the Ag-RDT was similar to what was predicted based on quantitative ANS viral loads and the inferred limit of detection of the ANS Ag-RDT being evaluated, indicating high-quality self-sampling. Nasal Ag-RDTs, even when used daily, can miss individuals infected with the Omicron variant and even those presumably infectious. Evaluations of Ag-RDTs for detection of infected or infectious individuals should be compared with a composite (multispecimen) infection status to correctly assess performance. Importance: We reveal three findings from a longitudinal study of daily nasal antigen rapid diagnostic test (Ag-RDT) evaluated against SARS-CoV-2 viral load quantification in three specimen types (saliva, nasal swab, and throat swab) in participants enrolled at the incidence of infection. First, the evaluated Ag-RDT showed low (44%) clinical sensitivity for detecting infected persons at all infection stages. Second, the Ag-RDT poorly detected (≤63%) time points that participants had high and presumably infectious viral loads in at least one specimen type. This poor clinical sensitivity to detect infectious individuals is inconsistent with the commonly held view that daily Ag-RDTs have near-perfect detection of infectious individuals. Third, use of a combination nasal-throat specimen type was inferred by viral loads to significantly improve Ag-RDT performance to detect infectious individuals

A structured jet explains the extreme GRB 221009A

Long-duration gamma-ray bursts (GRBs) are powerful cosmic explosions, signaling the death of massive stars. Among them, GRB 221009A is by far the brightest burst ever observed. Because of its enormous energy (Eᵢₛₒ ≈ 10⁵⁵ erg) and proximity (z ≈ 0.15), GRB 221009A is an exceptionally rare event that pushes the limits of our theories. We present multiwavelength observations covering the first 3 months of its afterglow evolution. The x-ray brightness decays as a power law with slope ≈ t^(−1.66), which is not consistent with standard predictions for jetted emission. We attribute this behavior to a shallow energy profile of the relativistic jet. A similar trend is observed in other energetic GRBs, suggesting that the most extreme explosions may be powered by structured jets launched by a common central engine

Investigating Deep Brain Stimulation of the Habenula: A Review of Clinical Studies

Objectives. The aim of this study was to examine the current scientific literature on deep brain stimulation (DBS) targeting the habenula for the treatment of neuropsychiatric disorders including schizophrenia, major depressive disorder, and obsessive-compulsive disorder (OCD). Materials and Methods. Two authors performed independent data base searches using the PubMed, Cochrane, PsycINFO, and Web of Science search engines. The data bases were searched for the query (“deep brain stimulation” and “habenula”). The inclusion criteria involved screening for human clinical trials written in English and published from 2007 to 2020. From the eligible studies, data were collected on the mean age, sex, number of patients included, and disorder treated. Patient outcomes of each study were summarized. Results. The search yielded six studies, which included 11 patients in the final analysis. Treated conditions included refractory depression, bipolar disorder, OCD, schizophrenia, and major depressive disorder. Patients with bipolar disorder unmedicated for at least two months had smaller habenula volumes than healthy controls. High-frequency stimulation of the lateral habenula attenuated the rise of serotonin in the dorsal raphe nucleus for treating depression. Bilateral habenula DBS and patient OCD symptoms were reduced and maintained at one-year follow up. Low- and high-frequency stimulation DBS can simulate input paths to the lateral habenula to treat addiction, including cocaine addiction. More data are needed to draw conclusions as to the impact of DBS for schizophrenia and obesity. Conclusions. The habenula is a novel target that could aid in reducing neuropsychiatric symptoms and should be considered in circuit-specific investigation of neuromodulation for psychiatric disorders. More information needs to be gathered and assessed before this treatment is fully approved for treatment of neuropsychiatric conditions

The 2 stream-exact single scattering (2S-ESS) radiative transfer model

The plane-parallel two-stream approximation is a popular radiative transfer approach for the calculation of fluxes and heating rates. However, it is typically not accurate enough for remote sensing applications involving the analysis of hyperspectral radiances. We present the 2 stream-exact single scattering (2S-ESS) radiative transfer model, which performs an exact calculation of single scattering in a spherically curved medium using an accurate treatment of the phase function and curved ray-tracing of the solar and line-of-sight paths, while approximating multiple scattering with the plane-parallel two-stream approach. The 2S-ESS model has three important features. First, it can be deployed for calculations in vertically inhomogeneous atmospheres. Second, the sphericity capability makes it applicable to large solar and/or viewing zenith angle scenarios such as those encountered close to sunrise or sunset. Third, it is fully linearized: in addition to generating radiances, the model can also compute Jacobians analytically with respect to any atmospheric or surface property (e.g., trace gases, aerosols and surface reflectance). These features of the model are especially useful for remote sensing retrieval applications. We examine the accuracy of this model for homogeneous slab and inhomogeneous multi-layer scenarios. The results show that this methodology introduces less than a few percent error in most situations, with the exception of heavy aerosol or cloud loading events, while providing three orders of magnitude improvement in computational efficiency. The code is publicly available along with documentation and test cases to assist the user

Efficient electrocatalytic valorization of chlorinated organic water pollutant to ethylene

Electrochemistry can provide an efficient and sustainable way to treat environmental waters polluted by chlorinated organic compounds. However, the electrochemical valorization of 1,2-dichloroethane (DCA) is currently challenged by the lack of a catalyst that can selectively convert DCA in aqueous solutions into ethylene. Here we report a catalyst comprising cobalt phthalocyanine molecules assembled on multiwalled carbon nanotubes that can electrochemically decompose aqueous DCA with high current and energy efficiencies. Ethylene is produced at high rates with unprecedented ~100% Faradaic efficiency across wide electrode potential and reactant concentration ranges. Kinetic studies and density functional theory calculations reveal that the rate-determining step is the first C–Cl bond breaking, which does not involve protons—a key mechanistic feature that enables cobalt phthalocyanine/carbon nanotube to efficiently catalyse DCA dechlorination and suppress the hydrogen evolution reaction. The nanotubular structure of the catalyst enables us to shape it into a flow-through electrified membrane, which we have used to demonstrate >95% DCA removal from simulated water samples with environmentally relevant DCA and electrolyte concentrations

Protoglobin-Catalyzed Formation of cis-Trifluoromethyl-Substituted Cyclopropanes by Carbene Transfer

Trifluoromethyl-substituted cyclopropanes (CF₃-CPAs) constitute an important class of compounds for drug discovery. While several methods have been developed for synthesis of trans-CF₃-CPAs, stereoselective production of corresponding cis-diastereomers remains a formidable challenge. We report a biocatalyst for diastereo- and enantio-selective synthesis of cis-CF₃-CPAs with activity on a variety of alkenes. We found that an engineered protoglobin from Aeropyrnum pernix (ApePgb) can catalyze this unusual reaction at preparative scale with low-to-excellent yield (6–55 %) and enantioselectivity (17–99 % ee), depending on the substrate. Computational studies revealed that the steric environment in the active site of the protoglobin forced iron-carbenoid and substrates to adopt a pro-cis near-attack conformation. This work demonstrates the capability of enzyme catalysts to tackle challenging chemistry problems and provides a powerful means to expand the structural diversity of CF₃-CPAs for drug discovery

Photometric Confirmation and Characterization of the Ennomos Collisional Family in the Jupiter Trojans

Collisional families offer a unique window into the interior composition of asteroid populations. Previous dynamical studies of the Jupiter Trojans have uncovered a handful of potential collisional families, two of which have been subsequently confirmed through spectral characterization. In this paper, we present new multiband photometric observations of the proposed Ennomos family and derive precise g − i colors of 75 candidate family members. While the majority of the targets have visible colors that are indistinguishable from background objects, we identify 13 objects with closely grouped dynamical properties that have significantly bluer colors. We determine that the true Ennomos collisional family is tightly confined to a’_p > 5.29 au and 0.45 < sin i_p < 0.47, and the majority of its confirmed members have near-solar spectral slopes, including some of the bluest objects hitherto discovered in the Trojan population. The property of distinctly neutral colors that is shared by both the Ennomos family and the previously characterized Eurybates family indicates that the spectral properties of freshly exposed surfaces in the Jupiter region are markedly different than the surfaces of uncollided Trojans. This implies that the processes of ice sublimation and space weathering at 5.2 au yield a distinct regolith chemistry from the primordial environment within which the Trojans were initially accreted. It also suggests that the Trojans were emplaced in their present-day location from elsewhere sometime after the initial population formed, which is a key prediction of recent dynamical instability models of solar system evolution