Red Mexicana de Repositorios Institucionales

    "Entrenamiento de competencias de investigación en estudiantes de educación media y superior. Guadalajara, Jalisco, México. 2006."

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    Colecci�n de investigadores miembros del Sistema Nacional de Investigadore

    Additional observations about Phaseolus rotundatus (Fabaceae), an endemic bean species from western Mexico

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    Further information is presented about Phaseolus rotundatus, a new bean species for western Mexico, where it appears to be endemic and endangered, with very few populations reported to date, and all outside current protected areas. The differences between P. rotundatus and P. marechalii (both of Phaseolus section Paniculati Freytag), the closest taxon with which it can be confused, are highlighted to confirm the validity of the former taxon

    Adenoviral gene therapy in hepatocellular carcinoma: A review

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    Background: Hepatocellular carcinoma is the third leading cause of cancer death. Single or multiple mutations in genes related to growth control, apoptosis, invasion and metastasis have been determined; so a better understanding of the molecular genetic basis of malignant transformation, tumor progression and host interaction has led to significant progress in the development of new therapeutic agents. The ability of adenovirus vectors to deliver and express genes at high yields in HCC treatment has been demonstrated and well documented over the last few years. Objective: To overview and provide an update of what has been accomplished in the field of adenoviral gene therapy and its application in hepatocellular carcinoma treatment. Methods : Original articles were searched using Pubmed and other medical databases to get the most representative and actual information to establish the current state of the investigation of Ad vectors in HCC. Results : Good results have been accomplished in preclinical models using new Ad vectors and especially AAV vectors, it is important to motivate further clinical trials to corroborate all the experience obtained. Conclusions : Ad and AAV must be considered as an opportunity to improve the quality of life and survival of HCC patients. © 2012 Asian Pacific Association for the Study of the Liver

    Adipokine pathways are altered in hippocampus of an experimental mouse model of Alzheimer’s disease

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    A growing body of evidence suggests that β-amyloid peptides (Aβ) are unlikely to be the only factor involved in Alzheimer’s disease (AD) aetiology. In fact, a strong correlation has been established between AD patients and patients with type 2 diabetes and/or cholesterol metabolism alterations. In addition, a link between adipose tissue metabolism, leptin signalling in particular, and AD has also been demonstrated. In the present study we analyzed the expression of molecules related to metabolism, with the main focus on leptin and prolactin signalling pathways in an APPswe/PS1dE9 (APP/PS1) transgenic mice model, at 3 and 6 months of age, compared to wild-type controls. We have chosen to study 3 months-old APP/PS1 animals at an age when neither the cognitive deficits nor significant Aβ plaques in the brain are present, and to compare them to the 6 months-old mice, which exhibit elevated levels of Aβ in the hippocampus and memory loss. A significant reduction in both mRNA and protein levels of the prolactin receptor (PRL-R) was detected in the hippocampi of 3 months old APP/PS1 mice, with a decrease in the levels of the leptin receptor (OB-R) first becoming evident at 6 months of age. We proceeded to study the expression of the intracellular signalling molecules downstream of these receptors, including stat (1–5), sos1, kras and socs (1–3). Our data suggest a downregulation in some of these molecules such as stat-5b and socs (1–3), in 3 months-old APP/PS1 brains. Likewise, at the same age, we detected a significant reduction in mRNA levels of lrp1 and cyp46a1, both of which are involved in cholesterol homeostasis. Taken together, these results demonstrate a significative impairment in adipokine receptors signalling and cholesterol regulation pathways in the hippocampus of APP/PS1 mice at an early age, prior to the Aβ plaque formation. © 2014 Serdi and Springer-Verlag Franc

    Aflatoxigenic feeding and its possible implications after pregnancy

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    Aflatoxlns are secondary metabolites produced by the fungi Aspergillus flaws, Aspergillus parasiticus and Aspergillus nomlus. It is known that they generate mycotoxins capable of causing carcinogenic mutagenic or teratogenic damage which have been detected in com, peanuts and grains In general.The molecular mechanism by which aflatoxlns are produced comes from the teratogenic effect and inhibition of cells division at the level of metaphase. Evaluate the association between the fetus' exposure to aflatoxigenic food and risk of death or low weight at birth. A case -control study was conducted among 513 women in a postpartum situation. They were interviewed retrospectively about their diet during the first two months of pregnancy. Daily intake denotes meaningful differences between the case and control groups over junk foods and corn tortilla respectively with p <0.05, and between the quality of the com tortillas and peanuts, which apparently cause synergism to the variable: smoking during pregnancy. Poor quality tortilla consumption and junk food are apparently Involved in the mortality of the fetus, it is considered as one of the possible causes of this event. Risk exists In both cases, high-risk foods are com tortillas with filaments between them (when separating them) and the unpleasant taste of peanuts

    Aggregation of the aqueous dodecyl-trimethylammonium bromide-didodecyldimethylammonium bromide system at low concentration

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    The dodecyltrimethylammonium bromide (DTAB)-didodecyldimethylammonium bromide (DDAB)-water system was studied to elucidate whether the mixed surfactant aggregates are mainly micelles or vesicles, and whether the surfactant-surfactant interaction is ideal or not. The regular solution theory of mixed micelles and the Israelachvili-Mitchell-Ninham (IMN) packing parameter of the aggregated mixture were used. The interaction between dissimilar surfactant species was found to be non-ideal, with a positive value of the regular solution theory interaction parameter. The steric hindrance interaction parameter of Huang and Somasundaran theory indicated that the introduction of DTAB into DDAB layers was favoured at very low DTAB content, but became highly unfavourable when the proportion of DTAB increased. The aggregates were systematically much richer in DDAB than the solution of interaggregates. The IMN values systematically were compatible with flat surfaces, i.e., lamellar liquid crystals and vesicles. The results may be explained by a different composition of the inner and outer monolayers in the bilayer structure of the vesicles

    AIP Conference Proceedings: Preface

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    [No abstract available

    Air pollutants and their correlation with medical visits for acute respiratory infections in children less than five years of age in urban Guadalajara, Mexico [Contaminantes atmosféricos y su correlación con infecciones agudas de las vías respiratorias en niños de Guadalajara, Jalisco]

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    Objective: To describe the correlation between the concentration levels of atmospheric air pollutants and the number of medical visits to IMSS, ISSSTE and of SSJ healthcare facilities of the Urban Area of Guadalajara between 2000-2002 by children under five years suffering from acute respiratory infections. Material and Methods: An ecological study was performed to describe the correlation between the interpolated monthly average modes, monthly mobile average of air pollutants: carbon monoxide, nitrogen dioxide, ozone, and particles with an aerodynamic diameter of less than 10 microns (PM10) and sulfur dioxide, and the number of medical visits per month due to acute respiratory infections in children under five years. Results: The air pollutants: carbon monoxide and nitrogen dioxide show a significant correlation with the incidence of acute respiratory infections in children less than five years of age in the Urban Area of Guadalajara. The correlation coefficients were: CO (r= 0.05) and NO2 (r= 0.09). Conclusions: Although the concentrations of air pollutants stay below the official limit, carbon monoxide and nitrogen dioxide affect the health of the child population of the Urban Area of Guadalajara. Although the monthly average mode and monthly mobile average does not exceed the established legislation, the registered maximums do exceed it; this indicates that although throughout most of the day there is no latent risk of population exposure to the air pollutants, during some hours of certain days there is a risk for the population of breathing air contaminated with concentrations higher than the limit, which can cause the development of acute respiratory infections

    Albumin mRNA in peripheral white blood cells of cirrhotic patients with a superimposed alcoholic hepatitis is associated to fatal outcome

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    The aim of this study was to analyze the relationship of plasma colloid osmotic pressure (COP), relative viscosity (η) and overall outcome on the expression of albumin (ALB) mRNA in peripheral white blood cells (PWBC) of cirrhotic patients with superimposed alcoholic hepatitis (LC + AH). ALB messanger was detected in PWBC by RT-nPCR in control individuals (C), patients with liver cirrhosis (LC) and LC + AH. A higher number of LC + AH patients were positive to ALB mRNA (67%), compared to C (30%) and LC (28%). COP was decreased in LC and LC + AH groups compared to C group. No statistically significant changes were detected in η in the different populations studied. Most of the LC + AH patients positive to peripheral ALB expression (87%) had a fatal outcome, compared to survivors (25%). Such difference was not observed with the conventional liver function tests or Maddrey's discriminant function. © 2002 Elsevier Science B.V. All rights reserved

    Alcoholism and liver disease in Mexico: Genetic and environmental factors

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    Alcoholism and cirrhosis, which are two of the most serious health problems worldwide, have a broad spectrum of clinical outcomes. Both diseases are influenced by genetic susceptibility and cultural traits that differ globally but are specific for each population. In contrast to other regions around the world, Mexicans present the highest drinking score and a high mortality rate for alcoholic liver disease with an intermediate category level of per capita alcohol consumption. Mexico has a unique history of alcohol consumption that is linked to profound anthropological and social aspects. The Mexican population has an admixture genome inherited from different races, Caucasian, Amerindian and African, with a heterogeneous distribution within the country. Thus, genes related to alcohol addiction, such as dopamine receptor D2 in the brain, or liver alcoholmetabolizing enzymes, such as alcohol dehydrogenase class I polypeptide B, cytochrome P450 2E1 and aldehyde dehydrogenase class 2, may vary from one individual to another. Furthermore, they may be inherited as risk or non-risk haplogroups that confer susceptibility or resistance either to alcohol addiction or abusive alcohol consumption and possibly liver disease. Thus, in this era of genomics, personalized medicine will benefit patients if it is directed according to individual or population-based data. Additional association studies will be required to establish novel strategies for the prevention, care and treatment of liver disease in Mexico and worldwide. © 2013 Baishideng Publishing Group Co., Limited. All rights reserved
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