A Prediction Model for Spot LNG Prices Based on Machine Learning Algorithms to Reduce Fluctuation Risks in Purchasing Prices

11Nsciescopu

Leak-Free Pathway Engineering for Construction of Optimal Cell Factory

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Developing a High-Resolution Microchip CE-SSCP System for Versatile Genetic Analysis

2

A Plug-in Repressor Library for Metabolic Flux Redistribution in Escherichia coli

2

Enhancing the Synthesis of 5-aminolevulinic Acid in E. coli Through a Elaborate Flux Distribution in the Glyoxylate Shunt Pathway

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Flux Optimization for Improved Hexanoic Acid Production in Escherichia coli

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High-performance fluorescence microscopy for precision diagnosis and surgery guiding.

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Biosynthesis of cadaverine from galactose in Escherichia coli through carbon flux redistribution

2

Human iPS-derived blood-brain barrier model exhibiting enhanced barrier properties empowered by engineered basement membrane

© 2022 Elsevier LtdThe basement membrane (BM) of the blood-brain barrier (BBB), a thin extracellular matrix (ECM) sheet underneath the brain microvascular endothelial cells (BMECs), plays crucial roles in regulating the unique physiological barrier function of the BBB, which represents a major obstacle for brain drug delivery. Owing to the difficulty in mimicking the unique biophysical and chemical features of BM in in vitro systems, current in vitro BBB models have suffered from poor physiological relevance. Here, we describe a highly ameliorated human BBB model accomplished by an ultra-thin ECM hydrogel-based engineered basement membrane (nEBM), which is supported by a sparse electrospun nanofiber scaffold that offers in vivo BM-like microenvironment to BMECs. BBB model reconstituted on a nEBM recapitulates the physical barrier function of the in vivo human BBB through ECM mechano-response to physiological relevant stiffness (∼500 kPa) and exhibits high efflux pump activity. These features of the proposed BBB model enable modelling of ischemic stroke, reproducing the dynamic changes of BBB, immune cell infiltration, and drug response. Therefore, the proposed BBB model represents a powerful tool for predicting the BBB permeation of drugs and developing therapeutic strategies for brain diseases.11Nsciescopu

Unveiling the role of Ni in Ru-Ni oxide for oxygen evolution: Lattice oxygen participation enhanced by structural distortion

Introducing Ni in Ru oxide is a promising approach to enhance the catalytic activity for the oxygen evolution reaction (OER). However, the role of Ni (which has a poor intrinsic activity) is not fully understood. Here, a RuNiOx electrode fabricated via a modified dip coating method exhibited excellent OER performance in acidic media, and neutral media for CO2 reduction reaction. We combined in-situ/operando X-ray absorption near-edge structure and on-line inductively coupled plasma mass spectrometry studies to unveil the role of the Ni introduced in the Ru oxide. We propose that the Ni not only transforms the electronic structure of the Ru oxide, but also produces a large number of oxygen vacancies by distorting the oxygen lattice structure at low overpotentials, increasing the participation of lattice oxygen for OER. This work demonstrates the real behavior of bimetallic oxide materials under applied potentials and provides new insights into the development of efficient electrocatalysts.11Ysciescopu