First case of B ALL with KMT2A-MAML2 rearrangement: a case report

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    International audienceBackground: A large number of chromosomal translocations of the human KMT2A gene, better known as the MLL gene, have so far been characterized. Genetic rearrangements involving KMT2A gene are frequently involved in lymphoid, myeloid and mixed lineage leukemia. One of its rare fusion partners, the mastermind like 2 (MAML2) gene has been reported in four cases of myeloid neoplasms after chemotherapy so far: two acute myeloid leukemias (AML) and two myelodysplasic syndrome (MDS), and two cases of secondary T-cell acute lymphoblastic leukemia (T-ALL).Case presentation: Here we report the case of a KMT2A - MAML2 fusion discovered by Next-Generation Sequencing (NGS) analysis in front of an inv11 (q21q23) present in a 47-year-old female previously treated for a sarcoma in 2014, who had a B acute lymphoid leukemia (B ALL).Conclusion: It is, to our knowledge, the first case of B acute lymphoblastic leukemia with this fusion gene. At the molecular level, two rearrangements were detected using RNA sequencing juxtaposing exon 7 to exon 2 and exon 9 to intron 1–2 of the KMT2A and MAML2 genes respectively, and one rearrangement using Sanger sequencing juxtaposing exon 8 and exon 2

    Spike-Time Precision and Network Synchrony Are Controlled by the Homeostatic Regulation of the D-Type Potassium Current

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    International audienceHomeostatic plasticity of neuronal intrinsic excitability (HPIE) operates to maintain networks within physiological bounds in response to chronic changes in activity. Classically, this form of plasticity adjusts the output firing level of the neuron through the regulation of voltage-gated ion channels. Ion channels also determine spike timing in individual neurons by shaping subthreshold synaptic and intrinsic potentials. Thus, an intriguing hypothesis is that HPIE can also regulate network synchronization. We show here that the dendrotoxin-sensitive D-type K current (I D) disrupts the precision of AP generation in CA3 pyramidal neurons and may, in turn, limit network synchronization. The reduced precision is mediated by the sequence of outward I D followed by inward Na current. The homeostatic downregulation of I D increases both spike-time precision and the propensity for synchronization in iteratively constructed networks in vitro. Thus, network synchronization is adjusted in area CA3 through activity-dependent remodeling of I D

    A groundwater-fed coastal inlet as habitat for the Caribbean queen conch Lobatus gigas-an acoustic telemetry and space use analysis

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    International audienceThe queen conch Lobatus (Strombus) gigas, a marine snail, is among the most important fisheries resources of the Caribbean region. To provide effective protection in marine reserves, a good understanding of its habitat usage is essential. Queen conches commonly inhabit marine habitats. In this study, its activity space in a marginal estuarine-like habitat, the groundwater-fed inlet of Xel-Ha (Mexico) was determined using high-resolution acoustic telemetry (VEMCO Positioning System). Thirty-eight animals with syphonal lengths ranging from 80 to 200 mm were tagged, 1 of them with an accelerometer tag. Their trajectories were recorded for 20 mo at 5 m resolution in a closely spaced array of 12 receivers. Space-time kernel home ranges ranged from 1000 to 18 500 m(2) with an ontogenetically increasing trend. Juveniles, subadults and most adults displayed continuous, non-patchy home ranges consistent with the typical intensive feeding activity by this fast-growing gastropod. In some adults, Levy flight-like fragmentation of home ranges was observed that may be related to feeding range expansion or other ecological drivers such as the breeding cycle. The observed small home ranges indicate that the space use of queen conch in this estuarine-like habitat is not conditioned by food availability, and despite environmental stress due to daily low-oxygen conditions, space use is comparable to that observed in more typical marine habitats. In a marine reserve context, the groundwater-fed inlet provides adequate protection of this inshore queen conch population. Such marginal habitats may play an increasingly important role in conservation management as pressure on populations increase


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    International audienc

    Species Distribution 2.0: An Accurate Time- and Cost-Effective Method of Prospection Using Street View Imagery

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    International audienceSpecies occurrence data provide crucial information for biodiversity studies in the current context of global environmental changes. Such studies often rely on a limited number of occurrence data collected in the field and on pseudo-absences arbitrarily chosen within the study area, which reduces the value of these studies. To overcome this issue, we propose an alternative method of prospection using geo-located street view imagery (SVI). Following a standardised protocol of virtual prospection using both vertical (aerial photographs) and horizontal (SVI) perceptions, we have surveyed 1097 randomly selected cells across Spain (0.1x0.1 degree, i.e. 20% of Spain) for the presence of Arundo donax L. (Poaceae). In total we have detected A. donax in 345 cells, thus substantially expanding beyond the now two-centuries-old field-derived record, which described A. donax only 216 cells. Among the field occurrence cells, 81.1% were confirmed by SVI prospection to be consistent with species presence. In addition, we recorded, by SVI prospection, 752 absences, i.e. cells where A. donax was considered absent. We have also compared the outcomes of climatic niche modeling based on SVI data against those based on field data. Using generalized linear models fitted with bioclimatic predictors, we have found SVI data to provide far more compelling results in terms of niche modeling than does field data as classically used in SDM. This original, cost-and time-effective method provides the means to accurately locate highly visible taxa, reinforce absence data, and predict species distribution without long and expensive in situ prospection. At this time, the majority of available SVI data is restricted to human-disturbed environments that have road networks. However, SVI is becoming increasingly available in natural areas, which means the technique has considerable potential to become an important factor in future biodiversity studies

    Fonds Annie-Hélène Dufour – Activités scientifiques : Des hommes se préparent à filmer une scène, alors qu'un autre est accroupi près d'un filet de pêche étendu sur le sol dans un jardin devant une habitation (Salins d'Hyères, Var)

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    Diapositive numérisée par Bruno Baudoin, Centre Camille Jullian, 2018-02.Photographie prise lors du tournage du film "Les yeux plus grands que les oreilles

    La technique du métal repoussé durant la Protohistoire mise en évidence par la découverte fortuite de quatre "salières" en Corse

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    National audienceThis article aims to present five objects recently and fortuitously discovered in Corsica ; more specifically in Balagne andthe Sartenais. These items, executed in a relatively soft lithic material (various steatites), display a specific morphologyenabling them to be allocated to a single functional and probably chronological assemblage. On the basis of their principalmorphological characteristics, we interpret these elements as supports for the moulds (“salières”) used in the context ofmetal sheet working with the repoussé technique. In the absence of the end products, the nature of this metal remains tobe ascertained. The appearance of the objects and the typology of the engraved basins enable comparisons to be madewith technical methods disseminated in the mid 2nd millennium BC in the eastern Mediterranean, particularly in theMycenean context. In this framework, the dual hypothesis of a technical transfer to Corsica during the Middle Bronze Ageand of a use of this savoir-faire in a funerary context is envisaged.Cet article vise à présenter cinq objets récemment et fortuitement découverts en Corse, plus précisément en Balagne etdans le Sartenais. Ces pièces, réalisées dans un matériau lithique généralement tendre (cortège des stéatites), offrent unemorphologie particulière permettant de les rattacher à un même ensemble fonctionnel et probablement chronologique.Au vu de leurs principaux caractères morphologiques, on envisage ces éléments comme des « salières », soit des supportsde matrices utilisées dans le cadre d’une métallurgie au repoussé sur feuille de métal. En l’absence des produits finis, lanature de ce métal reste à définir. L’aspect des pièces et la typologie des cuvettes gravées permettent des rapprochementsavec certains protocoles techniques diffusés vers le milieu du IIe millénaire en Méditerranée orientale, notamment encontexte mycénien. Dans ce cadre, la double hypothèse d’un transfert technique vers la Corse au cours du Bronze moyenet d’une utilisation de ce savoir-faire dans un cadre funéraire est envisagée

    Is a Unique Culture of Labour Migration Emerging in the Island Nations of Asia?

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    International audienceIn the space of three decades, three countries, the Philippines, Indonesia and Sri Lanka have become the main exporters of labor on a worldwide scale. Are island nations, such as the two archipelagos of the Philippines, Indonesia and the island of Sri Lanka, predisposed to the current large exodus of female migrant workers? Another record shared by these three countries: the very high percentage of women making up these migrant workers. This paper will analyze the principal factors of geography, population and the international labour market that explain this massive exportation of female migrant workers together with the state policies that are actively encouraging female migration. Beyond the determining geographical factor and the need to leave an overpopulated land to earn a living, we should indeed take into consideration the presence of a political will that contributed to the formation of a system of migration which is possibly particular to the island nations of Asia
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