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    Genome-wide identification and expression analysis of the C2H2-zinc finger transcription factor gene family and screening of candidate genes involved in floral development in Coptis teeta Wall. (Ranunculaceae)

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    © 2023 The authors. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.3389/fgene.2024.1349673Background: C2H2-zinc finger transcription factors comprise one of the largest and most diverse gene superfamilies and are involved in the transcriptional regulation of flowering. Although a large number of C2H2 zinc-finger proteins (C2H2-ZFPs) have been well characterized in a number of model plant species, little is known about their expression and function in Coptis teeta. C. teeta displays two floral phenotypes (herkogamy phenotypes). It has been proposed that the C2H2-zinc finger transcription factor family may play a crucial role in the formation of floral development and herkogamy observed in C. teeta. As such, we performed a genome-wide analysis of the C2H2-ZFP gene family in C. teeta. Results: The complexity and diversity of C. teeta C2H2 zinc finger proteins were established by evaluation of their physicochemical properties, phylogenetic relationships, exon-intron structure, and conserved motifs. Chromosome localization showed that 95 members of the C2H2 zinc-finger genes were unevenly distributed across the nine chromosomes of C. teeta, and that these genes were replicated in tandem and segmentally and had undergone purifying selection. Analysis of cis-acting regulatory elements revealed a possible involvement of C2H2 zinc-finger proteins in the regulation of phytohormones. Transcriptome data was then used to compare the expression levels of these genes during the growth and development of the two floral phenotypes (F-type and M-type). These data demonstrate that in groups A and B, the expression levels of 23 genes were higher in F-type flowers, while 15 genes showed higher expressions in M-type flowers. qRT-PCR analysis further revealed that the relative expression was highly consistent with the transcriptome data. Conclusion: These data provide a solid basis for further in-depth studies of the C2H2 zinc finger transcription factor gene family in this species and provide preliminary information on which to base further research into the role of the C2H2 ZFPs gene family in floral development in C. teeta.This research was supported by the National Natural Science Foundation of China (project grant no: 31971543), Major Special Projects of Yunnan Province (Biomedicine) (project number: 202102AA310045), Yunnan Provincial Science and Technology Department Agriculture Joint Special Project (projectnumber:202101BD070001-008)

    The effect of dose, settling time, shelf life, storage temperature and extractant on Moringa oleifera Lam. protein coagulation efficiency

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    © 2024 The Authors. Published by Elsevier. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1016/j.enmm.2024.100919The study explores green chemistry to purify drinking water using Moringa oleifera (MO) Lam. seeds. This is done by investigating the coagulation efficiency of MO seed extracts for treating moderately turbid water. The research reveals the influence of various factors such as dose, settling time, shelf life, storage temperature, and extractant (water and 1 M NaCl solution) on the coagulation efficiency of MO Lam. protein. The MO seed protein extracts (MOPE) dissolved in tap water, and 1 M NaCl solution was characterised for their performance at ambient temperature and 4 ℃. Within 3 h of MOPE treatment, the turbidity reduced by 90–93 % without significantly altering pH and total dissolved solids (TDS) or electrical conductivity (EC) of the treated water samples. Although the dose rate was found to increase with the storage time, the optimum Moringa oleifera dose was 30–50 mg/l. Overall, the refrigerated MOPE in NaCl offered an extended shelf life, exhibiting good coagulation for up to 7 days compared to 3–4 days for the non-refrigerated variant.Accepted versio

    Dreams of the Earth

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    An essay in the publication edited by the collective Chto Delat as part of the art and research project "Canary Archives" (HKW, Berlin, March 2022). This is shared under a creative commons licence

    Chronic pain evaluation in breast cancer patients using the Self-Report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS): a single center cross-sectional retrospective study

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    © 2024 The Authors. Published by VM Media Group. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.5603/PMPI.a2023.0027Background: Breast cancer is the most common cancer in India, and the number of survivors has increased over the last few years. Pain is one of the most common symptoms during cancer treatment due to either the disease itself or the adverse effects of treatment. The available data suggests that breast cancer patients have a high prevalence of neuropathic pain. Patients and methods: A cross-sectional observational study was done at the Department of Radiation Oncology, between November 2021 to June 2022. The patients were admitted and screened for participation, non-metastatic post-operative breast cancer on regular follow-up for 2 years after their last chemotherapy or radiotherapy and not having any chronic neuropathy disease and the Self-Report Leeds Assessment of Neuropathic Symptoms and Signs (S-LANSS) pain scale was used to assess the neuropathy pain status of patients. Patients’ demographics, clinical characteristics, and treatment of surgery, radiation therapy, and chemotherapy were collected and the comparison of the pain scores between the patients was analysed. Results: A total of 149 patients were included in the study. S-LANSS score was calculated in the study population and more than 61% of participants reported a score equal to or greater than 12, suggesting a predominant neuropathic pain component. Autonomic dysfunction, thermal pain, and allodynia were more prevalent in patients who underwent mastectomies compared to breast-conserving surgery. Whereas the dysesthesia and autonomic dysfunction score was higher in only the anthracycline group. Conclusions: The most important index for quality of life in cancer patients is the presence of persistent chronic pain and it is important to classify it accordingly in order to provide the best management. Using the S-LANSS score, the pattern of neuropathic pain can be determined early which leads to early intervention.This study did not receive any financial support/funding.Published onlin

    Imposter phenomenon and the early career researcher

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    This is a paper published in The lives of early career researchers published by HEPI, ISBN 9781915744180. The report is available on the publisher's website: https://www.hepi.ac.uk/2024/02/29/the-lives-of-early-career-researchers/British Academy

    Negotiating with technology: advancing the virtual in qualitative research methods

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    This is an author's accepted manuscript of an article published by Emerald in Qualitative Research Journal on 09/04/2024, available online: https://doi.org/10.1108/QRJ-12-2023-0187 The accepted manuscript may differ from the final published version.Purpose This study aims to describe key elements that are critical to virtual qualitative research especially while working with practitioners as participants. Design/methodology/approach This paper takes a reflexive researcher approach using a case study to explore how researchers adopted a qualitative research approach using digital technology. We use five principles suggested by Boland et al. (2022) as a framework to consider and reflect on our experiences as researchers and those of our participants. Findings We highlight the gatekeeper’s support, trusted relationship with the organisations, interpersonal skills of interviewers, stringent measures of securing data and shared experiences of interviewee and interviewers helped complete virtual research. We recommend that four key factors such as digital competency, feasibility, flexibility and resilience should be considered while undertaking or commissioning virtual, qualitative research studies. Originality/value Social care practitioners and qualitative researchers increasingly negotiate with digital technologies to undertake their work. In this paper, we evidence how online qualitative approaches can be effective provided challenges are dealt with diligently in each stage of the research process.Published onlin

    Strength and conditioning in dance: a systematic review and meta-analysis

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    © 2024 The Authors. Published by Wiley. This is an open access article available under a Creative Commons licence. The published version can be accessed at the following link on the publisher’s website: https://doi.org/10.1002/ejsc.12111To assess the evidence for the effect of strength and conditioning on physical qualities and aesthetic competence in dance populations, three electronic databases (PubMed, Scopus, SPORTDiscus) were searched (until September 2022) for studies that met the following criteria: (i) dancers aged >16 years; (ii) structured strength and conditioning intervention; and (iii) with physical qualities and aesthetic competence as outcome measures. Methodological quality and risk of bias of the included studies were assessed through the systematic review tool “QualSyst”. Meta-analyses of effect sizes (Hedges’ g) with forest plots explored the effects of the strength and conditioning interventions. Thirty-six studies met the inclusion criteria and were included in this review. Meta-analysis indicated strength and conditioning significantly (p < 0.05) improved lower body power (g = 0.90, 95%CI: 0.53 to 1.27), upper body strength (g = 0.98, 95%CI: 0.39 to 1.57), lower body strength (g = 1.59, 95%CI: 0.97 to 2.22), and flexibility (g = 0.86, 95%CI: 0.05 to 1.66). Strength and conditioning interventions were found to be effective at improving physical qualities in dancers, recommending their participation in additional sessions to enhance overall fitness and ultimately dance performance. It is recommended that future strength and conditioning intervention research should include sample size calculations, with participants recruited from a specific dance genre and skill level in order to evaluate how strength and conditioning influences dance performance

    Public education for mental health: Revisiting its intervention potential

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    © 2024 Odisha Journal of Psychiatry. Published under a Creative Commons licence: https://journals.lww.com/odjp/fulltext/2023/19020/public_education_for_mental_health__revisiting_its.2.aspxIt is well known that public knowledge about mental illnesses is not at an expected level, and misinformation and stigma continue to be commonplace. These factors have a negative impact on appropriate and timely help seeking, adherence to treatment, and consequently on the clinical outcomes. There are robust public education materials and resources available through various platforms, such as the print and electronic media and the Internet. In fact, there is information overload, and a considerable proportion of the information is inaccurate, unscientific, and unreliable. Considering this, there is a need for appropriate guidance to be provided by the mental health professionals to the patients, caregivers, and general public. Public education for mental health is not only helpful but is also an effective intervention that is not adequately used. It should be actively encouraged and practiced routinely. This may improve the mental health literacy of the general public; the help seeking, engagement, and adherence of the patients with the treatment process would possibly be better, and these may help the intervention and outcome of mental illnesses

    Fructosamine: a negative acute phase reactant

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    This is an author's accepted manuscript of correspondence published by SAGE in Journal of Diabetes Science and Technology on 31/05/2017. The published version can be accessed here: https://doi.org/10.1177/1932296817712527 The accepted manuscript may differ from the final published version.Published versio

    Relative energy deficiency in dance (RED-D): a consensus method approach to REDs in dance

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    © Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.Relative Energy Deficiency in Sport (REDs) is a potentially severe, challenging, broad-spectrum syndrome with potential negative health and performance outcomes. The numerous research publications and International Olympic Committee consensus statements relating to REDs testify to the challenges faced in early identification or screening, diagnosis, and management. Like sport, dance, in its simplest form, can be identified as an activity resulting in physiological energy demands and, as such, requires appropriate energy availability concerning energy expenditures. However, the specificity of physiological and psychological demands in dance must be considered when considering REDs. An environment where physical activity can exceed 30 hours per week and where culture may instil a value that thinness is required puts dancers at increased risk for REDs. The purpose of this study was to provide dance specific guidance dance on this complex condition. A RAND/UCLA Delphi Panel method with nominal group technique was used to review the literature from REDs to evaluate how it may relate to dance. In addition to the EP, which was assembled from a multidisciplinary background with expertise in REDs and multiple genres of dance, six focus groups were commissioned. Four of the focus groups were drawn from the EP members and two additional focus groups formed by dancers and artistic leaders. These panels were used to guide the development of a RED-D Diagnosis Pathway, Management Plan and Risk stratification and Return to Dance Pathway. The dance specific pathways are designed to be a practical tool for guiding and supporting clinicians managing RED-D. Furthermore, this paper represents an important focus of this area in dance and serves to stimulate discussion and further research within the sector

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