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1334 research outputs found
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The Practice and the Challenges of Japanese-style Bookkeeping Education in China
2024幎3æãçè
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Transforming growth factor-β (TGF-β) inhibits cell proliferation and promotes cell differentiation. In human HuH-7 hepatocellular carcinoma cells, TGF-β reduces the expression of the α-fetoprotein (AFP) gene, a marker molecule for hepatocellular carcinoma cells. In this case, the amount of AT motif-binding factor-1 (ATBF1) mRNA, which encodes a transcriptional repressor of the AFP gene, was not changed. This suggests the involvement of factors that are induced by TGF-β and interact with ATBF1. The enhancer of split- and hairy-related protein-2 (SHARP-2) is a basic helix-loop-helix transcriptional repressor and an interacting protein of ATBF1. In this study, we examined whether TGF-β regulates the expression of the SHARP-2 gene in HuH-7 cells. TGF-β induced the SHARP-2 mRNA level within 1 hr. Next, to explore the signaling pathway, HuH-7 cells were pretreated with various inhibitors and then treated with TGF-β. Inhibitors of TGF-β type I receptor, phosphoinositide 3-kinase, protein kinase C, Jun N-terminal kinase, mitogen-activated protein kinase, and RNA polymerase II completely or partially diminished the induction of the SHARP-2 mRNA level by TGF-β. Finally, a reporter plasmid containing from -3,700 to +265 region of the SHARP-2 gene were transfected into HuH-7 cells and treated with TGF-β, but no change in promoter activity was observed. Thus, we concluded that TGF-β increased the level of SHARP-2 mRNA via multiple pathways at the transcription level of the SHARP-2 gene and that SHARP-2 is a candidate protein mediating TGF-β-repression of the AFP gene.departmental bulletin pape
The Regulation of the Expression of Various Transcription Factor Genes and the Identification of Target Genes in Mouse 3T3-L1 Adipocytes
SHARP familyã¯è»¢åæå¶å åã§ãããSHARP-1ããã³SHARP-2ã®2çš®é¡ã®ã¢ã€ãœãã©ãŒã ãååšãããZhx2ã¯ãZhx1ãZhx2ãZhx3ã®3ã€ã®ã¢ã€ãœãã©ãŒã ãããªãZhx転åæå¶å åfamilyã®äžå¡ã§ããããããã®è»¢åå åã¯ãããŠã¹3T3-L1èèªçŽ°èã«ãããŠãã»ã«ã³ãã¡ãã»ã³ãžã£ãŒã§ããcAMPãç£çããã¢ããã«é
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A Trial Online Class for Database Management
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The Relationship between the Actual Status of Students' Dietary Habits, Their Food Intake Frequency, and Their Level of Mental Health
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The Current Situation and Issues Surrounding the Regional Transfer of Athletic Club Activities
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Measuring the Salt Intake from Soba Noodles in Soba Noodle Restaurants : A Pilot Study
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