Tackling TB:How can researchers and cultural institutions benefit each other?

Verdant Works is Dundee's industrial heritage museum, set in a former jute mill near the University of Dundee. Why would they be interested in a biology exhibition? This poster offers a practical, ABCDEF guide to how to plan engagement for mutual benefit

The Craft Hub Journey:Project Catalogue

Introducing the Craft Hub project and the International Exhibition ‘Investigating Craft Practices across Europe’, including its journey across Europe, the artistic curation and set-up methodology for a replicable, accessible and sustainable design, adapting to seven unique exhibition spaces and content. The recurring themes, Heritage, Sustainability, Experimentation, Technological Innovation, Empowerment and Social Inclusion create common threads running through the activities and research carried out by each Craft Hub partner

Design and high-throughput implementation of MALDI-TOF/MS-based assays for Parkin E3 ligase activity

Parkinson’s disease (PD) is a progressive neurological disorder that manifests clinically as alterations in movement as well as multiple non-motor symptoms including but not limited to cognitive and autonomic abnormalities. Loss-of-function mutations in the gene encoding the ubiquitin E3 ligase Parkin are causal for familial and juvenile PD. Among several therapeutic approaches being explored to treat or improve the prognosis of patients with PD, the use of small molecules able to reinstate or boost Parkin activity represents a potential pharmacological treatment strategy. A major barrier is the lack of high-throughput platforms for the robust and accurate quantification of Parkin activity in vitro. Here, we present two different and complementary Matrix-Assisted Laser Desorption/Ionization Time-Of-Flight Mass Spectrometry (MALDI-TOF/MS)-based approaches for the quantification of Parkin E3 ligase activity in vitro. Both approaches are scalable for high-throughput primary screening to facilitate the identification of Parkin modulators

A phase 2 trial investigating the efficacy and safety of the mPGES-1 inhibitor vipoglanstat in systemic sclerosis-related Raynaud's

OBJECTIVE: Our objective was to test the hypothesis, in a double-blind, placebo-controlled study that vipoglanstat, an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1) which decreases prostaglandin E2 (PGE2) and increases prostacyclin biosynthesis, improves RP.METHODS: Patients with systemic sclerosis (SSc) and ≥7 RP attacks during the last screening week prior to a baseline visit were randomised to four weeks treatment with vipoglanstat 120 mg or placebo. A daily electronic diary captured RP attacks (duration and pain) and Raynaud's Condition Score, with change in RP attacks/week as primary end point. Cold challenge assessments were performed at baseline and end of treatment. Exploratory endpoints included patients' and physicians' global impression of change, Assessment of Scleroderma-associated Raynaud's Phenomenon questionnaire, mPGES-1 activity, and urinary excretion of arachidonic acid metabolites.RESULTS: Sixty-nine subjects received vipoglanstat (n = 33) or placebo (n = 36). Mean weekly number of RP attacks (baseline; vipoglanstat 14.4[SD 6.7], placebo 18.2[12.6]) decreased by 3.4[95% CI -5.8;-1.0] and 4.2[-6.5;-2.0] attacks per week (p= 0.628) respectively. All patient reported outcomes improved, with no difference between the groups. Mean change in recovery of peripheral blood flow after cold challenge did not differ between the study groups. Vipoglanstat fully inhibited mPGES-1, resulting in 57% reduction of PGE2 and 50% increase of prostacyclin metabolites in urine. Vipoglanstat was safe and well tolerated.CONCLUSION: Although vipoglanstat was safe, and well tolerated in a dose achieving full inhibition of mPGES-1, it was ineffective in SSc-related RP. Further development and evaluation of vipoglanstat will therefore be in other diseases where mPGES-1 plays a pathogenetic role.</p

‘Free text is essentially the enemy of what we’re trying to achieve’: the framing of a national vision for delivering digital police contact

Police organisations in England and Wales, as in many other contexts, are increasingly shifting crime reporting and other public-facing contact online. In this paper we explore the beliefs, motivations, and objectives of those tasked with ‘delivering’ the ‘vision’ of digital police contact at the strategic national level. We use Goffman’s concept of frames – the set of expectations an actor brings to a situation or process – to understand how participants enacted this 'channel shift’ (Wells et al., 2023), the ends they were seeking to meet, and how different interests came to be designed-in to the contact architecture. We suggest that the primary frame centred around notions of efficiency and demand management. Running alongside this is a secondary frame of customer service, where it is assumed that the public also wish for the efficient delivery of this technologically mediated service. This, we suggest, is likely to be only a partial reflection of what people want when contacting police; but the framing of 'contact’ as a separate deliverable by those delivering this agenda serves to occlude or evade this point. Technology, we argue, imprints itself on the context by appearing to offer a convenient solution to problems of public wants and police needs

Teachers’ Use of Knowledge in Curriculum Making:Implications for Social Justice

Curriculum work is a key part of teachers’ practice and involves engaging with different types of knowledge. The way in which teachers use this knowledge will influence pupils’ experience of the curriculum in their classroom. In the globalised world of the 21st century, knowledge questions are important considerations, as schooling is situated in inequitable systems and social structures. This qualitative research study examined teachers’ use of knowledge as they made the curriculum in their classrooms. Data were generated via interviews with primary school teachers in Scotland and thematically analysed. Five types of knowledge were identified and then critically examined using Nancy Fraser’s framework for social justice. This enabled examination of the implications of teachers’ use of knowledge in their curriculum work. Findings were congruous with previous research on this topic, highlighting the complexity of curriculum work. Our analysis suggests that while the focus on ‘pupil-centred’ education is important, as it acts to recognise pupils in curriculum work, the redistribution of knowledge is a key consideration in the globalised and digitised present day. Digital tools and spaces not only provide access to information but also provide new opportunities for inequity and oppressive social relations; continual reflection on the knowledge flow into schools is an important consideration for both teachers and policy-makers.</p

Resting-state EEG signatures of Alzheimer's disease are driven by periodic but not aperiodic changes

Electroencephalography (EEG) has shown potential for identifying early-stage biomarkers of neurocognitive dysfunction associated with dementia due to Alzheimer's disease (AD). A large body of evidence shows that, compared to healthy controls (HC), AD is associated with power increases in lower EEG frequencies (delta and theta) and decreases in higher frequencies (alpha and beta), together with slowing of the peak alpha frequency. However, the pathophysiological processes underlying these changes remain unclear. For instance, recent studies have shown that apparent shifts in EEG power from high to low frequencies can be driven either by frequency specific periodic power changes or rather by non-oscillatory (aperiodic) changes in the underlying 1/f slope of the power spectrum. Hence, to clarify the mechanism(s) underlying the EEG alterations associated with AD, it is necessary to account for both periodic and aperiodic characteristics of the EEG signal. Across two independent datasets, we examined whether resting-state EEG changes linked to AD reflect true oscillatory (periodic) changes, changes in the aperiodic (non-oscillatory) signal, or a combination of both. We found strong evidence that the alterations are purely periodic in nature, with decreases in oscillatory power at alpha and beta frequencies (AD &lt; HC) leading to lower (alpha + beta) / (delta + theta) power ratios in AD. Aperiodic EEG features did not differ between AD and HC. By replicating the findings in two cohorts, we provide robust evidence for purely oscillatory pathophysiology in AD and against aperiodic EEG changes. We therefore clarify the alterations underlying the neural dynamics in AD and emphasize the robustness of oscillatory AD signatures, which may further be used as potential prognostic or interventional targets in future clinical investigations.</p