Sul ritardo nella nomina dei giudici costituzionali da parte del Parlamento in seduta comune

The article examines the issue of delays in the appointment of constitutional judges by the Parliament in joint session, a problem that undermines the full functionality of the Constitutional Court and its ability to effectively perform its duties. Following an initial reflection on the importance of ensuring a complete and consistently operational Court, the analysis explores the causes of parliamentary inertia. In its concluding section, the article evaluates potential remedies, including proposals for constitutional reforms as well as measures aimed at facilitating the appointment process within the framework of the current constitutional system

Training Load, Official Match Locomotor Demand, and Their Association in Top-Class Soccer Players During a Full Competitive Season

: Riboli, A, Nardi, F, Osti, M, Cefis, M, Tesoro, G, and Mazzoni, S. Training load, official match locomotor demand, and their association in top-class soccer players during a full competitive season. J Strength Cond Res 39(2): 249-259, 2025-To examine training load and official match locomotor demands of top-class soccer players during a full competitive season and to evaluate their association. Twenty-five top-class soccer players competing in UEFA international competitions were included. The season was divided into 2 different categories: 2 matches (M2) or 3 matches (M3) in 8 days. Starters and nonstarters were classified. Total distance (TD), high-speed running (HSR, 15-20 km·h-1), very high-speed running (VHSR, 20.1-24 km·h-1), sprint (SPR, >24.1 km·h-1), and accelerations/decelerations (Acc + Dec, >3 m·s2) were recorded. Trivial to moderate differences (p 0.05) in M2 and M3 with ∼5 to ∼29% match-to-match variability depending on metrics. Total load (i.e., training plus match loads) was higher (p < 0.05, ES: 0.75/1.61) in starters than nonstarters, because of a higher match load and no difference in the training load. Very high-speed running and SPR accumulated during training sessions were largely to very largely (r = 0.60 to 0.72) associated with TD, HSR, VHSR, and Acc + Dec covered during official match; VHSR and TD during training were largely to very largely (r = 0.57 and 0.71) associated with SPR and Acc + Dec during official match. In conclusion, (a) congested periods seemed to not affect official match locomotor performance; (b) practitioners may consider high week-by-week workload variability for individualizing training prescriptions, especially for nonstarters; and (c) the VHSR and SPR accumulated during training were associated with the official match locomotor demands, and it may be considered for maximizing performance

POLITICHE ATTIVE, POVERTÀ E VULNERABILITÀ SOCIALE: QUALI STRUMENTI PER FAVORIRE IL LAVORO CARCERARIO?

Il saggio affronta il tema delle condizioni di lavoro dei detenuti attraverso la lente della povertà e della vulnerabilità sociale. Muove dall'equiparazione del lavoro carcerario a quello reso nel mercato libero, nella disciplina e nelle tutele sostanziali e processuali, e si propone di valorizzare le politiche attive per promuovere l’occupabilità dei detenuti durante la reclusione e dopo la scarcerazione, in una prospettiva di garanzia della dignità della persona e di effettivo reinserimento nella società

miR-449a/miR-340 reprogram cell identity and metabolism in fusion-negative rhabdomyosarcoma

: Rhabdomyosarcoma (RMS), the most common pediatric soft tissue sarcoma, arises in skeletal muscle and remains in an undifferentiated state due to transcriptional and post-transcriptional regulators. Among its subtypes, fusion-negative RMS (FN-RMS) accounts for the majority of diagnoses in the pediatric population. MicroRNAs (miRNAs) are non-coding RNAs that modulate cell identity via post-transcriptional regulation of messenger RNAs (mRNAs). In this study, we identify miRNAs impacting FN-RMS cell identity, revealing miR-449a and miR-340 as major regulators of the cell cycle and p53 signaling. Through miR-eCLIP technology, we demonstrate that miR-449a and miR-340 directly target transcripts involved in glycolysis and mitochondrial pyruvate transport, inhibiting the mitochondrial pyruvate carrier (MPC) complex. Pharmacological MPC inhibition induces a similar metabolic shift, reducing metastatic potential and leading to cell cycle exit. Overall, miR-449 and miR-340 orchestrate FN-RMS cell identity, positioning MPC inhibition as a strategy to shift FN-RMS cells toward a non-tumorigenic, quiescent state

Evaluating Lichen Sclerosus in Phimosis: Insights From a Multidisciplinary Retrospective Study

Objectives: This study aimed to evaluate the prevalence of lichen sclerosus (LS) in male patients undergoing circumcision for phimosis, emphasising the significance of a multidisciplinary approach in the early diagnosis and management of this condition. Methods: A retrospective analysis was performed on 841 male patients who underwent circumcision at a high-volume medical centre between 2001 and 2023. Data were collected on clinical diagnoses made by both dermatologists and urologists, along with the corresponding histological findings. Logistic regression models were utilised to assess diagnostic accuracy and the relationship between clinical suspicion and histological confirmation. Results: Histological confirmation of LS was identified in 30.6% of the cases. Dermatologists demonstrated a diagnostic accuracy of 81.8%, whereas urologists showed an accuracy of 46.1%. The evaluations conducted by dermatologists exhibited a significant correlation with histological confirmation of LS (odds ratio 4.81; 95% confidence interval: 1.96–11.80; p = 0.001). Conclusions: This study elucidates the differences in diagnostic accuracy between dermatologists and urologists in identifying LS in patients undergoing circumcision for phimosis, highlighting the necessity of a multidisciplinary approach to improve the diagnostic process. Furthermore, the epidemiological data obtained from this research offer valuable insights into the prevalence of LS and the associated diagnostic challenges within a substantial patient cohort

Long-Term Eosinophil Depletion: A Real-World Perspective on the Safety and Durability of Benralizumab Treatment in Severe Eosinophilic Asthma

Abstract: Background/Objectives: Benralizumab is an anti-IL-5 receptor alpha monoclonal antibody that induces the near-complete depletion of eosinophils. This study aimed to evaluate the long-term safety and effectiveness of benralizumab in patients with severe eosinophilic asthma (SEA) over an extended 48-month follow-up period, offering one of the longest real-world perspectives available. Methods: This was a single-arm, retrospective, observational, multicenter study involving 123 SEA patients treated with benralizumab at a dosage of 30 mg every 4 weeks for the first 3 doses and then every 8 weeks. The safety endpoints focused on the frequency and nature of adverse events and the likelihood that they were induced by benralizumab. The efficacy endpoints focused on lung function, asthma exacerbations and control, and oral corticosteroid use. Results: Benralizumab, consistent with its mechanism of action, led to the rapid and nearly complete depletion of eosinophils. In total, 26 adverse events (21.1%) were observed, with 1.6% related to the treatment and 0.8% categorized as serious (vagal hypotension). Bronchitis was the most common unrelated adverse event (15.4%), occurring between months 36 and 38. Importantly, benralizumab effectiveness and safety were maintained consistently across the 48-month duration, resulting in significant improvements in lung function and reductions in oral corticosteroid use and exacerbation frequency. Conclusions: Benralizumab demonstrated a favorable safety profile, comparable to previously published studies, with perdurable effectiveness in controlling SEA and reducing oral corticosteroid use. Finally, this study provides evidence that near-complete eosinophil depletion does not increase long-term safety risks and supports benralizumab as a reliable treatment option for SEA patients

Mitochondrial DNA copy number is significantly increased in bipolar disorder patients and is correlated with long-term lithium treatment

Mitochondrial dysfunctions have been reported in bipolar disorder (BD), but their role in the etiopathogenesis of BD as well as their implications in modulating response to pharmacological treatments with psychotropic medications have been scarcely explored. Mitochondrial DNA copy number (mtDNA-cn) has been linked to mitochondria functioning, and, despite some degree of inconsistence, previous findings showed that BD patients present significant differences in mtDNA-cn compared to healthy controls. Here we measured mtDNA-cn in a sample of 89 patients with BD and 78 healthy controls (HC). Patients in the BD sample were treated either with lithium (n = 47) and characterized as responders (n = 22) or non-responders (n = 25), or with other mood stabilizers (n = 42). BD patients had larger mtDNA-cn compared to HC (adjusted model: F2=9.832; p = 0.000095; contribution of diagnosis F1= 10.798; p = 0.001). When the BD sample was stratified for treatment exposure, mtDNA-cn was lower in patients treated with lithium compared to those treated with other mood stabilizers (adjusted model: F4=23.770, p = 7.0929E-13; contribution of treatment: F1=54.300, p = 1.55E-10). Moreover mtDNA-cn was higher in patients treated with other mood stabilizers compared to controls and Li-treated BD patients (F3=28.125, p = 1.36E-14; contribution of groups F2=36.156, p = 1.25E-13). Finally, there was no difference in mtDNA-cn levels in lithium responders compared to non-responders and neither between the two diagnostic groups (BD type 1 and 2). Our findings suggest that BD may be associated with mitochondrial dysfunctions, and that exposure to lithium but not to other mood stabilizers may restore these abnormalities, though this does not appear correlated with the clinical efficacy of lithium