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This is an update request for the document Reduced cerebrospinal fluid BACE1 activity in multiple sclerosis by N. Mattsson, M. Axelsson, S. Haghighi, C. Malmestrom, G. Wu, R. Anckarsater, S. Sankaranarayanan, U. Andreasson, S. Fredrikson, A. Gundersen, L. Johnsen, T. Fladby, A. Tarkowski, E. Trysberg, A. Wallin, Henrik Anckars├Ąter, J. Lycke, O. Andersen, A. J. Simon, K. Blennow and H. Zetterberg

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