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This is an update request for the document Mutations in ORC1, encoding the largest subunit of the origin recognition complex, cause microcephalic primordial dwarfism resembling Meier-Gorlin syndrome. by Louise S Bicknell, Sarah Walker, Anna Klingseisen, Tom Stiff, Andrea Leitch, Claudia Kerzendorfer, Carol-Anne Martin, Patricia Yeyati, Nouriya Al Sanna, Michael Bober, Diana Johnson, Carol Wise, Andrew P Jackson, Mark O'Driscoll and Penny A Jeggo

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