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This is an update request for the document Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition by J. Irving, E. Matheson, L. Minto, H. Blair, M. Case, C. Halsey, I. Swidenbank, F. Ponthan, R. Kirschner-Schwabe, S. Groeneveld-Krentz, J. Hof, J. Allan, C. Harrison, J. Vormoor, A. von Stackelberg and C. Eckert

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