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This is an update request for the document Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1 by Verónica D'annunzio, Virginia Perez, Tamara Mazo, Marina Cecilia Muñoz, Fernando Pablo Dominici, Maria Cecilia Carreras, Juan José Poderoso, Junichi Sadoshima and Ricardo Jorge Gelpi

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